Executive Operations, CEO Office

Pathos • New York, NY

4d • $100,000 - $130,000 • Hybrid

About The Position

This role owns the foundational logistics of the CEO’s office—calendar management, travel, and daily operations. However, what separates this role from a traditional Executive Assistant position is the scope, the stakes, and the leverage. Pathos is a 50-person company with four clinical-stage oncology programs, a ~$3 billion valuation, co-development partnerships with top-five pharma companies, and an active Series E fundraise. The CEO’s week spans investor meetings, board sessions, pharma partner discussions, and clinical milestone reviews. You are the operational backbone that ensures nothing falls through the cracks. At Pathos, the "Office of the CEO" functions as the operational hub for the entire executive leadership team. While your primary mandate is the CEO, you will actively support the broader C-suite on various high-leverage matters, ensuring the company’s senior leadership moves with total alignment and zero friction. You will own investor meeting preparation, board material production, congress logistics (ASCO, ESMO, ASH, JPM), pharma briefings, and the institutional memory of executive commitments. You will chase people down, follow up relentlessly, and anticipate needs before being asked. To operate at this scale, this role runs on AI. You will use AI agents to assemble board packages, compile competitive intelligence, draft communications, and build congress schedules. AI handles the first pass; you bring the judgment and the relentless follow-through. One person equipped with AI agents can run an executive office that would traditionally require a small team—and that is exactly our expectation. This role is distinct from, but works in close partnership with, the Chief of Staff. The Chief of Staff acts as the CEO’s strategic arm—running cross-functional projects and driving company-wide initiatives. You own the CEO’s operational rhythm—preparation, logistics, materials, and follow-through. You will work closely together to ensure the executive office is both strategically and operationally flawless.

Requirements

• 2–5 years of professional experience in executive support, operations, or a fast-paced business environment (startup, high-growth tech, healthcare, or biotech).
• Exceptional organizational architecture. You can manage dozens of parallel workstreams without dropping a single thread. You have a system, and it works.
• Strong written communication. You can draft a clear, concise executive memo or announcement that sounds like it came from the CEO.
• Relentless follow-through. You are "impossible to shake loose." If a deadline is approaching, you chase it. If something falls through the cracks, it is because someone else dropped it, not because you stopped watching.
• Comfort operating at a high-intensity pace in a highly fluid, 50-person company building four clinical-stage assets.
• Absolute trustworthiness with highly confidential information (non-negotiable).

Nice To Haves

• Experience supporting C-level executives (ideally a CEO or founder) at a high-growth or venture-backed company.
• Contextual understanding of healthcare, biotech, life sciences, or drug development.
• Experience with investor relations, board governance, fundraising logistics, or major conference coordination.
• A genuine curiosity and willingness to adopt AI tools (ChatGPT, Claude, Copilot) as core workflow infrastructure.
• A natural instinct for building repeatable systems and organizing chaos.

Responsibilities

• Own the CEO’s calendar, travel, and daily logistics. Manage scheduling across time zones and competing priorities with zero friction.
• Serve as the central operational node for the broader executive leadership team, providing critical coordination and support for C-suite initiatives, offsites, and cross-functional leadership matters.
• Coordinate the leadership team’s meeting agendas and track cross-functional action items. When a task is assigned, you track it until it is executed.
• Act as the connective tissue between the executive office and every function (Clinical, BD, Legal, Engineering, Finance). Route, prioritize, and triage incoming requests for leadership's attention.
• Handle confidential information, including fundraising, personnel decisions, legal matters, and board-level strategy.
• Manage expenses, vendor relationships, and the operational details that keep the executive office running smoothly.
• Own the Series E preparation workstream. Research investors, pull the latest portfolio data from Foundry, coordinate with Finance on materials, and build comprehensive briefing packages.
• Lead the logistical production of quarterly board meetings. Coordinate cross-functional materials, manage timelines, verify data accuracy, and anticipate director inquiries.
• Prepare briefings for joint development committees (e.g., AstraZeneca), collaboration reviews (e.g., Alphamab), and new partnership discussions.
• Direct logistics for major oncology conferences (ASCO, ESMO, ASH, AACR, JPM). Build schedules, coordinate travel, identify high-priority sessions, and ensure optimal use of the leadership team's time on the ground.
• Deploy AI agents for meeting prep, document drafting, competitive intelligence, data compilation, and follow-up tracking.
• Create repeatable AI workflows for recurring tasks (board packages, investor updates, congress prep) so quality improves and execution time shrinks every cycle.
• Write clear, concise executive communications (i.e, investor updates, board memos, internal announcements, and partner correspondence) working closely with communications as necessary.
• Manage the production of monthly investor updates, leadership meeting agendas, and company-wide memos.
• Maintain a rigorous record of decisions made, commitments given, and action items assigned across the executive team. When the CEO needs to recall an agreement made with a partner six months ago, you have it instantly.

Benefits

• Unprecedented Visibility: You will see exactly how a generational company scales from the inside—fundraising, board dynamics, pharma partnerships, clinical milestones, and high-level strategy.
• Accelerated Learning: The complexity-to-headcount ratio here is unlike traditional biotech. You are operating at the center of a ~$3 billion company moving at unprecedented velocity.
• Compounding Skillset: You will utilize AI tools daily to execute at a level most executive operations professionals have not yet experienced, building a skillset that will define the future of the function.
• Expanding Scope: The best operators in this role expand their impact over time, evolving from managing the CEO’s office to becoming indispensable to the operational rhythm of the entire company.

What This Job Offers

• Job Type: Full-time
• Career Level: Executive
• Education Level: No Education Listed