Executive Director, Global Medical Affairs (remote)

Lilly • Indianapolis, IN

5d • $177,000 - $308,000 • Remote

About The Position

The Executive Director, Global Medical Affairs will serve as the Global Medical Affairs Lead for Centessa’s lead orexin receptor 2 agonist program, cleminorexton. This strategic leadership role is responsible for developing and executing global medical strategy across the product lifecycle, with a focus on launch readiness, scientific leadership, evidence generation, external engagement, and cross-functional partnership. The role serves as the medical voice of the asset, integrating scientific evidence, stakeholder insights, and patient needs into business decisions.

The successful candidate will lead global medical affairs activities and partner with commercial, market access, HEOR, clinical development, regulatory affairs, patient advocacy, and regional medical teams to deliver integrated launch strategies. The position reports to the Head of Medical Affairs and partners closely with senior leadership across the organization.

The role is remote and based in the United States, with occasional travel of approximately 20%.

Requirements

• Advanced scientific or clinical degree (MD, PharmD, or PhD).
• Minimum 10 years of Medical Affairs leadership experience.
• Experience in neuroscience, sleep medicine, neurology, psychiatry, or rare disease.
• Demonstrated experience leading at least one successful global product launch.
• Experience serving as a global medical lead for late-stage development or commercial products.
• Strong understanding of global medical affairs, evidence generation, payer evidence requirements, and commercialization readiness.
• Proven ability to drive strategy in a matrix environment.
• Proven track record of close collaboration with commercial, market access, HEOR, regulatory affairs, and clinical development organizations.
• Exceptional communication, presentation, and stakeholder management skills.

Nice To Haves

• Five years of global Medical Affairs experience is preferred.
• Experience with successful launches across North America, Europe, and Asia-Pacific markets is highly preferred.

Responsibilities

• Lead the global medical affairs strategy and tactical execution plan for cleminorexton.
• Serve as the Global Medical Affairs Lead and a core member of the cross-functional asset team.
• Align medical strategy with corporate objectives, clinical development milestones, and commercialization plans.
• Establish long-range medical affairs planning to support regulatory approvals, launch readiness, and lifecycle management.
• Identify emerging scientific opportunities, evidence gaps, and stakeholder needs to inform future development.
• Lead medical launch preparedness activities across major global markets.
• Partner with commercial, market access, HEOR, regulatory affairs, and regional medical teams to develop integrated launch strategies.
• Coordinate medical affairs deliverables in line with strategy and launch timelines, including scientific platforms, training content, medical information resources, publications, congress activities, and insights generation.
• Support pre-launch and launch planning, including global payer engagement strategies and value communication with HEOR and market access.
• Build and maintain relationships with global key opinion leaders, investigators, professional societies, and patient advocacy organizations.
• Lead scientific advisory boards, expert consultations, and other insight-gathering initiatives.
• Represent Centessa at major scientific congresses and industry meetings.
• Serve as a scientific ambassador and subject matter expert for orexin biology and sleep-wake disorders.
• Act as a strategic partner to commercial, market access, HEOR, regulatory, clinical development, patient advocacy, and corporate affairs.
• Contribute medical expertise to brand strategy, payer engagement, disease-state education, and scientific communication initiatives.
• Partner on the development of scientific platforms, publication strategies, educational programs, and medical training.
• Provide medical review and guidance for externally facing scientific materials in compliance with applicable regulations and company policies.

Benefits

• Company bonus eligibility, depending in part on company and individual performance.
• Eligibility to participate in a company-sponsored 401(k).
• Pension.
• Vacation benefits.
• Eligibility for medical, dental, vision, and prescription drug benefits.
• Flexible benefits, such as healthcare and/or dependent day care flexible spending accounts.
• Life insurance and death benefits.
• Certain time-off and leave-of-absence benefits.
• Well-being benefits, including an employee assistance program, fitness benefits, and employee clubs and activities.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree