Executive Director, Chemical Engineering Lead

Madrigal Pharmaceuticals • Conshohocken, PA

4d • $276,205 - $328,644

About The Position

Madrigal is seeking an Executive Director, Chemical Engineering Lead to guide chemical engineering strategy and execution oversight. The role ensures drug substance and drug product processes are scalable, safe, and transferable to external manufacturing. The position defines equipment and process suitability expectations, leads process safety and manufacturability assessments, and supports the resolution of scale-up constraints. It also ensures engineering inputs align with validation strategy and sustained performance after transfer, enabling reliable supply execution.

Requirements

• Bachelor of Science or higher in Chemical Engineering.
• 18 or more years of process or chemical engineering experience supporting GMP manufacturing and technology transfer.
• Demonstrated leadership in scale-up, safety, and collaboration with external manufacturers.
• Strong cross-functional influence and structured problem-solving skills.

Nice To Haves

• Advanced degree in Chemical Engineering.
• Experience supporting SDD process scale-up and solvent and safety considerations.
• Experience supporting validation and PPQ readiness activities.

Responsibilities

• Set engineering standards for scale-up readiness, safety, and process and equipment fit.
• Support drug substance and drug product teams in defining scalable process parameters and operating ranges.
• Lead engineering contributions to technology transfer, process safety reviews, and risk assessments.
• Drive yield, throughput, and cycle-time improvement opportunities with external partners.
• Ensure engineering documentation supports validation readiness and audit expectations.

Benefits

• Equity for all employees.
• Flexible paid time off.
• Medical, dental, vision, and life and disability insurance.
• 401(k) offerings, including traditional and Roth plans and an employer match.
• Voluntary benefits, including supplemental life insurance and legal services.
• Mental health benefits through the Employee Assistance Program for employees and their family.

What This Job Offers

• Job Type: Full-time
• Career Level: Executive