Engineer II, Instrumentation integration

Exact Sciences • San Diego, CA

7d • $100,400 - $150,600 • Hybrid

About The Position

At Exact Sciences, we’re helping change how the world prevents, detects and guides treatment for cancer. We give patients and clinicians the clarity needed to make confident decisions when they matter most. Join our team to find a purpose-driven career, an inclusive culture, and robust benefits to support your life while you’re working to help others. The Engineer II works independently to resolve moderately complex instrument escalations and participates in the ongoing refinement of equipment support processes. This role expands technical responsibilities to include multi-instrument troubleshooting, data analysis for performance trending, and process documentation updates. It acts as a direct escalation partner for Lab Service Engineers and increasingly collaborates with developers, vendors, and IT for diagnostic and support coordination. The Engineer II supports service readiness for new systems and contributes to recurring issue reduction efforts by identifying patterns and implementing structured fixes. This position also plays an emerging role in mentoring peers and supporting knowledge-sharing within the team.

Requirements

• Bachelor’s Degree in Engineering or related field; or Associates degree in Engineering, Technology, Electronics, or similar field with 2+ years of relevant industry experience; or High School Diploma/General Education Degree and 4+ years of relevant experience in Engineering or related field as outlined in the essential duties in lieu of Bachelor’s Degree.
• 3+ years of experience in an engineering or technical support role.
• 3+ years of experience performing root cause analysis on analytical instrumentation and systems.
• Demonstrated understanding of clinical lab regulations.
• Possesses advanced knowledge of engineering theories, practices and procedures and applies this knowledge and skills to complete assignments.
• Proficient in Microsoft Office including Word, Excel, PowerPoint, and Outlook.
• Demonstrated ability to perform the Essential Duties of the position with or without accommodation.
• Authorization to work in the United States without sponsorship.

Nice To Haves

• 6+ years’ of experience in engineering, technical support, or related fields.
• 3+ years' hands-on experience installing, troubleshooting, and repairing Hamilton STAR liquid handling systems, serving as a subject matter expert.
• Experience with standard molecular biology techniques, such as nucleic acid isolation, RNA/DNA quantification, PCR, and RT-PCR.
• 3D modeling and printing/ prototyping experience.
• Experience with Next-Generation Sequencing (NGS).
• Experience servicing analytical laboratory instrumentation.
• Understanding of networking and software connectivity of analytical instrumentation.
• Working knowledge of CAP and CLIA regulations.
• Automated liquid handler maintenance and scripting.
• Process and workflow mindset.
• 3+ years of experience with data analysis and query engines.
• 3+ years of experience in a FDA or CAP/CLIA regulated industry.

Responsibilities

• Troubleshoot and resolve moderately complex issues across multiple types of analytical instrumentation, including multi-instrument workflows (e.g., Hamilton STARlet, NGS sequencers, Promega Maxwell, Thermo QS5).
• Identify trends in instrumentation failures and propose minor adjustments to service workflows or documentation to prevent recurrence.
• Collaborate with IT and instrumentation developers to escalate basic connectivity or software issues that contribute to recurring performance problems.
• Lead root cause analysis efforts for common issues on supported platforms and document recommended preventive measures.
• Lead resolution of service escalations within established time requirements, applying both mechanical expertise and analytical problem-solving skills.
• Analyze log files and performance metrics to identify failure patterns, root causes, and areas for reliability improvement.
• Apply CAP/CLIA compliance knowledge when investigating and resolving equipment issues.
• Interface with IT to support basic instrument networking and connectivity issues.
• Collaborate cross-functionally to address customer questions related to equipment use, maintenance, and service enhancement opportunities.
• Conduct experiments to reproduce customer issues; create and interpret queries and data to support investigations and improvements.
• Serve as liaison between internal teams and OEM vendors for complex issue escalation and technical problem-solving.
• Identify top service bottlenecks and proactively lead improvement initiatives with high business value.
• Lead or contribute to small-scale initiatives for process improvement, documentation updates, and new tool implementation.
• Provide informal mentorship to Engineer I team members and contribute to the development of troubleshooting resources and knowledge sharing.
• Assist in the technical transfer, setup, and validation of new hardware and instrumentation across laboratories.
• Actively participate in development initiatives and represent instrumentation needs in core team meetings.
• Build strong relationships with customers and internal teams through effective communication, responsiveness, and service excellence.
• Demonstrate high mechanical and analytical aptitude and the ability to plan, prioritize, and manage tasks independently.
• Maintain personal technical knowledge and stay up to date on new tools, systems, and regulatory expectations.
• Collaborate in a positive, inclusive team environment and act with curiosity, integrity, and accountability.
• Support and comply with the company’s Quality Management System and applicable safety and regulatory requirements (e.g., OSHA, CLIA).

Benefits

• paid time off (including days for vacation, holidays, volunteering, and personal time)
• paid leave for parents and caregivers
• a retirement savings plan
• wellness support
• health benefits including medical, prescription drug, dental, and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level