Early Development Program Lead – Cambridge

Insmed Incorporated

8d•$255,000 - $347,500•Remote

About The Position

Insmed is seeking an Early Development Program Lead to serve as the scientific and operational leader for one or more early-stage drug development programs emerging from the Cambridge Research team. Reporting to the Chief Development Officer, this experienced translational clinical science leader will bridge discovery and development, guiding cross-functional teams from late-stage lead optimization through IND. The role engages development functions to support scientific rigor, strategic alignment, and timely delivery of program milestones. The position is fully remote and may be performed from anywhere while staying connected to the Insmed team and community. Occasional travel for team meetings or events is expected, approximately 10% domestically and/or internationally. The role provides scientific and project leadership across small molecule and/or oligonucleotide programs, integrates multidisciplinary data to inform candidate selection, and coordinates internal and external partners. It also supports program planning, decision-making, risk management, reporting, and preparation of key development documents. The successful candidate will have a relevant PhD, extensive pharmaceutical or biotech industry experience, a record of leading matrix teams and advancing programs through IND into first-in-human studies, and experience engaging with regulatory agencies in early development. The stated annual pay range is $255,000–$347,500.

Requirements

PhD in Medicinal Chemistry, Pharmacology, Pharmaceutical Sciences, Translational Medicine, Biochemistry, or a related discipline directly relevant to small molecule or oligonucleotide drug discovery and development.
15 or more years of experience in the pharmaceutical or biotech industry, demonstrating increasing levels of responsibility.
At least 5 years of industry experience in small molecule drug and/or oligonucleotide therapeutic discovery and development.
Demonstrated experience leading cross-functional drug development matrix teams in a pharmaceutical or biotech environment.
Track record of advancing programs from lead optimization through IND and into first-in-human (FIH) studies.
Experience engaging with regulatory agencies, including FDA and EMA, in early development settings such as pre-IND or INTERACT meetings and Type B/C meetings.
Highly effective, proactive communication skills and ability to manage by influence in a matrix environment.
Ability to build trust, inspire confidence, clearly articulate challenges and opportunities, and align teams through complex decision-making.

Responsibilities

Serve as the primary bridge between the Cambridge Research organization and Insmed’s Development functions.
Lead and coordinate cross-functional early development teams across medicinal chemistry, CMC, formulation, biology, toxicology, DMPK/ADME, translational science, regulatory, clinical, and patient advocacy.
Provide strategic scientific project leadership and oversight, and help define project objectives.
Define and oversee execution of the scientific strategy for assigned small molecule and/or ASO programs from late lead optimization through IND.
Establish productive working relationships with CROs and CDMOs and, with relevant Insmed functions, identify, assess, and oversee outsourced activities.
Integrate multidisciplinary data to drive candidate selection decisions aligned with the Target Product Profile.
Facilitate resource allocation and decision-making across functions with competing priorities and timelines.
Set program ambition, define and drive strategy through key milestones, and remain accountable for timelines, execution, and deliverables needed for program continuation.
Identify and manage scientific, CMC, and clinical risks, including mitigation and contingency planning.
Work with Program Management to develop, maintain, and communicate integrated project plans, timelines, budgets, and risk registers.
Lead cross-functional discussions to develop early Target Product Profiles.
Facilitate team meetings, drive decisions, and ensure accountability across functions.
Prepare and present program updates to senior leadership and governance committees.
Collaborate with portfolio management to align programs with corporate strategy.
Provide updates to the Cambridge Development Program team about upcoming project needs and development milestones.
Author and review early TPPs, project charters, and integrated development plans, and support regulatory briefing documents.
Present program status and support presentations of scientific findings to internal leadership.

Benefits

Comprehensive medical, dental, and vision coverage and mental health support.
Annual wellbeing reimbursement and access to an Employee Assistance Program (EAP).
Generous paid time off policies.
Fertility and family-forming benefits and caregiver support.
Flexible work schedules with purposeful in-person collaboration.
401(k) plan with a competitive company match.
Annual equity awards and participation in the Employee Stock Purchase Plan (ESPP).
Company-paid life and disability insurance.
Company Learning Institute with access to LinkedIn Learning, skill-building workshops, leadership programs, mentorship connections, and networking opportunities.
Employee resource groups, service and recognition programs, and opportunities to connect, volunteer, and give back.