Director, Medicinal Chemistry

Magnet Biomedicine • Boston, MA

1d • $220,000 - $250,000

About The Position

Magnet Biomedicine is seeking an experienced medicinal chemist to lead drug discovery programs through preclinical candidate selection. The role requires deep knowledge of medicinal and synthetic chemistry and a proven track record of advancing drug discovery programs. The Director will lead multidisciplinary teams, coordinate internal and external chemistry resources, develop molecular optimization strategies, interpret complex biological and molecular data, and mentor team members. Magnet is a biotechnology company focused on discovering oral molecular glues using its TrueGlue platform, with programs in oncology, immunology, and inflammation.

Requirements

• Ph.D. in Organic Chemistry with 7 or more years of experience, or a master's degree in Chemistry with 10 or more years of experience and leadership in small-molecule drug discovery.
• Strong track record of creativity and problem-solving in medicinal and organic chemistry, demonstrated through publications and patents.
• At least 4 years of experience leading, coaching, and enabling high-performing teams.
• Ability to solve complex multiparametric problems and use computational and empirical data to drive molecular optimization.
• Working knowledge of adjacent fields critical to drug discovery and development, including ADMET, in vitro and in vivo pharmacology, and CMC.
• Strong interpersonal, written, and oral communication skills.
• Self-motivated and adaptable, with the ability to thrive in a dynamic, interdisciplinary environment.

Nice To Haves

• Experience working with external CRO partners.
• Experience with BRo5 optimization.
• Experience with molecular glues.

Responsibilities

• Lead multidisciplinary drug discovery project teams from hit identification through candidate selection.
• Coordinate, lead, and manage internal and external chemistry teams using modern synthetic and parallel chemistry approaches and techniques.
• Formulate medicinal chemistry plans and strategies to drive molecular optimization using structure-based drug design, property predictions, computational methods, and modeling approaches.
• Use modern visualization approaches to interpret and analyze complex biological and molecular data.
• Collaborate within cross-functional teams and foster cross-disciplinary relationships to advance project and company goals.
• Guide, manage, motivate, mentor, and support direct reports toward company goals.
• Lead by example and positively influence the organization.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree