Scientist I, Medicinal Chemistry

Revolution Medicines•Redwood City, CA

1d•Onsite

About The Position

Revolution Medicines is seeking a scientifically talented individual to join its Discovery Research organization as a Scientist I, Medicinal Chemistry. This individual-contributor role is a key member of an integrated, multidisciplinary drug discovery team and will contribute to discovering new drug candidates. The position focuses on designing and synthesizing biologically active compounds to support structure–activity relationship (SAR) work, analyzing biological data, and using structure-based drug design (SBDD) to design analogs. The scientist will plan and execute synthetic routes, purify final targets, identify alternative routes and methods to address challenges, and present research findings to the Medicinal Chemistry team and management. The role also involves collaboration with medicinal chemists, cross-functional colleagues, and external teams, including contract research organizations (CROs). The position is onsite at Revolution Medicines’ headquarters in Redwood City, California. The full-time base salary range is $119,000–$149,000 USD, adjusted for local market. The company also describes its total rewards program as including competitive cash compensation, equity awards, benefits, and learning and development opportunities.

Requirements

Ph.D. with a background in synthetic organic chemistry.
0–3 years of postdoctoral or relevant pharmaceutical/biotechnology industry experience.
Strong understanding of synthetic organic and medicinal chemistry.
Experience with NMR, HPLC, and mass spectrometry techniques.
Familiarity with modern synthetic organic chemistry techniques and instrumentation.
Knowledge of synthetic methodologies and ability to independently design and execute synthetic procedures.
Strong written and verbal communication skills for working with interdepartmental teams.
Ability to multitask, work efficiently and in an organized manner, and collaborate as a team player in a dynamic, fast-paced environment.

Nice To Haves

Demonstrated experience in total synthesis of complex molecules, including multistep route design, synthetic problem-solving, and stereochemical control.
Experience in beyond Rule-of-Five (bRo5) small-molecule drug discovery.
Experience in oncology drug discovery research.

Responsibilities

Design and synthesize biologically active compounds to support SAR.
Analyze biological data.
Use structure-based drug design to design analogs.
Plan and execute synthetic routes, including synthesis and purification of final targets.
Recommend alternative synthetic routes, research methods and techniques, and seek solutions to synthetic challenges.
Present research findings to the Medicinal Chemistry team and management.
Partner in scientific activities with medicinal chemists and cross-functional team members, fostering an environment where ideas are shared.
Collaborate with external teams and contract research organizations (CROs).