Scientist I, Medicinal Chemistry

Revolution Medicines•Redwood City, CA

21h•$119,000 - $149,000•Onsite

About The Position

Revolution Medicines is seeking a scientifically talented individual to join its Discovery Research organization as a Scientist I, Medicinal Chemistry. This individual contributor will be a key member of an integrated, multidisciplinary drug discovery team and contribute to discovering new drug candidates. The role is onsite at the company’s headquarters in Redwood City, California. The Scientist will design and synthesize biologically active compounds, analyze biological data, and use structure-based drug design to create analogs. They will plan and execute synthetic routes, purify final targets, identify alternative routes and methods to solve challenges, and present findings to the Medicinal Chemistry team and management. The role also involves collaborating with medicinal chemists, cross-functional colleagues, and external teams, including contract research organizations.

Requirements

Ph.D. with a background in synthetic organic chemistry.
0–3 years of postdoctoral or relevant pharmaceutical/biotechnology industry experience.
Strong understanding of synthetic organic and medicinal chemistry.
Experience with NMR, HPLC, and mass spectrometry techniques.
Familiarity with modern synthetic organic chemistry techniques and instrumentation.
Proficiency in synthetic methodologies and ability to independently design and execute synthetic procedures.
Strong written and verbal communication skills for working with interdepartmental teams.
Ability to multitask, work efficiently and in an organized manner, and collaborate as a team player in a dynamic, fast-paced environment.

Nice To Haves

Demonstrated experience in total synthesis of complex molecules, including multistep route design, synthetic problem-solving, and stereochemical control.
Experience in beyond Rule-of-Five (bRo5) small-molecule drug discovery.
Experience in oncology drug discovery research.

Responsibilities

Design and synthesize biologically active compounds to support structure–activity relationship (SAR) studies.
Analyze biological data.
Design analogs using structure-based drug design (SBDD).
Plan and execute synthetic routes and synthesize and purify final targets.
Recommend alternative synthetic routes, research new methods and techniques, and seek out solutions to challenges.
Present research findings to the Medicinal Chemistry team and management.
Partner in scientific activities with medicinal chemists and cross-functional team members, fostering an environment where ideas are shared.
Collaborate with external teams and contract research organizations (CROs).