Director, Medicinal Chemistry Synthesis

Parabilis Medicines•Cambridge, MA

10h•$200,000 - $240,000•Onsite

About The Position

Parabilis Medicines is seeking a highly talented and motivated Director, Medicinal Chemistry Synthesis to advance its Helicons™ therapeutic modality, including degraders and other induced-proximity approaches, through first-in-class and best-in-class programs and toward candidate nomination. The role reports to the Vice President of Medicinal Chemistry Synthesis and is based on-site, with in-person meetings required. The posting describes product leadership responsibilities involving AI, informatics, and data products, including setting product vision and roadmaps, gathering stakeholder requirements, prioritizing AI-driven tools, and working with software engineers and data scientists to deliver and improve products. It also calls for using AI in day-to-day work and measuring product adoption and impact. These responsibilities appear alongside the role’s medicinal chemistry focus in the supplied description. The successful candidate will bring deep synthetic chemistry expertise, lead projects and external CRO partnerships, collaborate across functions, and deliver against timelines aligned with company objectives. Experience in solid-phase peptide synthesis is preferred.

Requirements

Ph.D. in Chemistry.
10+ years of industry experience.
Demonstrated expertise in synthetic route design and execution across a range of molecular complexities.
Strong background in synthetic methodology development, complex problem solving, and modern small-molecule synthesis.
Experience leading projects and managing external CRO partnerships.
Collaborative approach and desire to incorporate novel synthetic tools to improve efficiency.
Innovative thinking, a growth mindset, and willingness to challenge conventional approaches.
Passion for drug discovery and advancing novel therapeutic modalities.
Excellent communication, organizational, and collaboration skills.
Ability to independently prioritize and deliver against timelines aligned with company objectives.
Demonstrated ability to utilize AI tools for day-to-day work; baseline proficiency is expected.
Ability to work on-site and attend in-person meetings.

Nice To Haves

Experience in solid-phase peptide synthesis.

Responsibilities

Advance Helicons™, including degraders and other induced-proximity approaches, through drug-discovery programs toward candidate nomination.
Own the product vision and roadmap for AI, informatics, and data products, translating organizational strategy into an executable plan.
Partner with stakeholders across research, development, clinical, and business functions to gather requirements, build trust, and prioritize needs.
Drive the portfolio of AI-driven tools by identifying opportunities to automate and scale work and prioritizing them into workstreams.
Work with software engineers and data scientists to scope plans, timelines, and tradeoffs.
Put functional prototypes in front of users early, gather feedback, and iterate.
Make pragmatic decisions within timelines while protecting the long-term sustainability and quality of deliverables.
Use AI tools in research, requirements, specifications, prototypes, and analysis, and set an example for scaling team output.
Define measures of success for products, track adoption and impact, and hold the team and self accountable to those measures.
Lead projects and manage external CRO partnerships.
Independently prioritize work and deliver against timelines aligned with company objectives.