Director, Clinical Operations

Revolution Medicines•Redwood City, CA

1d•$211,000 - $264,000•Hybrid

About The Position

Revolution Medicines is seeking a Clinical Operations leader to oversee the execution and management of company clinical trials, including CRO oversight. The role partners strategically on development, management, and execution of Clinical Development Plans for assigned programs, including timelines, budgets, and resource requirements. The Director leads and deploys Clinical Operations staff, manages CROs and selected study vendors, and collaborates with internal functions to achieve study goals. The position also ensures trials remain inspection-ready and improves processes that affect trial management and deliverables. The role requires extensive pharmaceutical or biotechnology Clinical Operations experience, including leadership of global Phase 1–3 trials and project and first-line management. The position may require travel of approximately 25%. The listed onsite Redwood City base salary range is $211,000–$264,000; the range is adjusted for local market and individual factors.

Requirements

RN or bachelor's or master's degree in biological sciences or a health-related field.
15 years of direct Clinical Operations experience in the pharmaceutical or biotechnology industry; relevant indirect experience may also meet the requirement.
At least 9 years of project and first-line management experience.
Experience leading and managing global Phase 1–3 clinical trials within designated timelines, resources, and budgets.
Strong working knowledge of FDA regulations, ICH guidelines, and GCP.
Experience with vendor management and CRO oversight.
Ability to perform complex analysis, draw relevant conclusions, and implement appropriate solutions.
Ability to pivot and be solution-oriented while considering long-term impacts on clinical trials, responsibilities, and inspection readiness.
Strong analytical, negotiation, and persuasion skills.
Ability to manage time demands, incomplete information, and unexpected events.
Outstanding organizational skills and ability to multitask and prioritize.
Excellent interpersonal, verbal, and written communication skills.
Decision-making skills.
Comfort working in a fast-paced company environment and adjusting workload as priorities change.
Proficiency in Microsoft Office Suite, including Outlook, Word, Excel, and PowerPoint.
Travel may be required, approximately 25%.

Nice To Haves

Proficiency with MS Project and/or Smartsheet.
Success collaborating with vendor systems or portals, such as eTMF, EDC, IRT, and CTMS.
Oncology experience, early-stage and/or late-stage, is strongly preferred.
Knowledge of or familiarity with clinical trial operations in ex-US regions.
Experience working with cooperative group studies and investigator-sponsored trials.

Responsibilities

Adhere to Clinical Standard Operating Procedures, Good Clinical Practice, and International Conference on Harmonization guidelines.
Oversee successful management of all aspects of clinical trials within timelines and designated program budgets.
Serve as a strategic thought partner in developing, managing, and executing Clinical Development Plans for assigned clinical programs, including timelines, budgets, and resource requirements.
Identify critical-path activities and articulate and mitigate risks to clinical trial conduct.
Plan and deploy Clinical Operations staff for project and non-project-related tasks.
Lead line management responsibilities, including hiring, performance management, career development, and mentorship.
Manage and oversee CROs and selected study vendors, ensuring milestones are achieved within budget and timeline and evaluating vendor performance using metrics and KPIs.
Lead team meetings and collaborate with internal functional groups, including Clinical Development, Regulatory, QA, Finance, and Legal, to achieve clinical study goals.
Ensure clinical trials remain inspection-ready throughout their lifecycle.
Improve processes affecting clinical trial management and deliverables, including contingency plans, while maintaining an effective Clinical Operations team and building relationships with functional leaders.