Serif Biomedicines: CMC mRNA Development Co-Op
About The Position
This position is open exclusively to current Northeastern University Co-Op students. The work period is from January 2027 to June 2027. This is a full-time, 40 hours per week position with 5 days in office. Serif Biomedicines, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. Serif Biomedicines was founded by Flagship Pioneering's venture creation engine that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Requirements
- Current student enrolled in a master’s or bachelor’s degree in chemical engineering, Biology, Biotechnology, or Biochemistry.
- Familiarity with enzymatic reactions, such as in vitro transcription (IVT)
- Familiarity with HPLC and FPLC purification and instrumentation
- Knowledge of TFF and instrumentation.
- Familiarity with nucleic acid analytics, including running gel and capillary electrophoresis,and interpreting data.
- Knowledge of aseptic/RNase-free handling and operations.
- Excellent time and project management.
- Excellent oral and written communication skills.
- Proficient with Microsoft Office programs.
Responsibilities
- Synthesize and purify mRNA products for preclinical studies.
- Optimize and scale up enzymatic reactions for mRNA synthesis.
- Optimize and scale up purification workflow for nucleic acids using chromatography, filtration, and enzymatic reactions to remove byproducts and/or endotoxin.
- Perform high-throughput screens to optimize RNA generation through in vitro transcription (IVT) and automated purification instrumentation.
- Operate and maintain lab instruments, including Fast Protein Liquid Chromatography (FPLC) (e.g. AKTA systems), Tangential Flow Filtration (TFF) systems, and biosafety cabinets (BSCs).
- Characterize mRNA drug substance using analytical techniques, such as fragment analysis, UV spectroscopy, gel electrophoresis, and endotoxin measurement.
- Maintain an electronic laboratory notebook and miscellaneous documentation.
- Present findings at team meetings or cross-functional meetings.
Benefits
- Compensation reflects the real work you take on.
- Strong co-ops are considered for future opportunities across Flagship and its portfolio companies, not just for this one role.
- Retirement benefits may be available after completing a set number of hours.
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Intern
Education Level
Associate degree
