Clinical Contract Manager

Tango Therapeutics • Boston, MA

5d • Hybrid

About The Position

We are seeking a Clinical Contract Manager (CCM) to lead the end-to-end clinical site contracting process in support of our growing clinical portfolio. This role will serve as the primary sponsor contact for Contract Research Organization (CRO) partners and internal stakeholders across Clinical, Legal, Finance, and Compliance. In a fast-paced, small biotech environment, the CCM will drive the development, negotiation, execution, and maintenance of Clinical Trial Agreements (CTAs), ensuring alignment with trial timelines, budget, and regulatory requirements. This individual will play a key role in enabling timely site activation, CTA maintenance as per trial requirements, proactively identifying and mitigating risks, and ensuring compliance of CTAs with applicable regulations and internal standards. The ideal candidate is highly collaborative, detail-oriented, and comfortable operating in a hands-on environment, with a focus on building scalable processes, tools, and best practices to support efficient and compliant clinical trial execution.

Requirements

• 5+ years of trial management experience
• 3+ years in site management
• Bachelor’s degree in Life Sciences, Pharmacy or related field
• Experience working in global clinical development organization
• Experience in outsourcing and oversight
• Familiarity with clinical trial systems (e.g., CTMS, eTMF) and operational metrics, KPIs, and KRIs
• Familiarity with site contracting requirements and healthcare compliance (Fair Market Value, SOX Act, Sunshine Act)
• Knowledge in ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines

Nice To Haves

• Experience in Oncology development
• Direct experience with site health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections

Responsibilities

• Lead the end-to-end clinical site contracting process.
• Serve as the primary sponsor contact for CRO partners and internal stakeholders.
• Drive the development, negotiation, execution, and maintenance of Clinical Trial Agreements (CTAs).
• Ensure alignment with trial timelines, budget, and regulatory requirements.
• Enable timely site activation.
• Maintain CTAs as per trial requirements.
• Proactively identify and mitigate risks.
• Ensure compliance of CTAs with applicable regulations and internal standards.
• Build scalable processes, tools, and best practices.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level