Chief of Staff

ITF Therapeutics•Concord, MA

About The Position

Reporting to the President of ITF Therapeutics US, the Chief of Staff serves as a strategic thought partner to the President and an integrator across the leadership team. The role helps shape enterprise priorities, improve decision-making, translate strategy into coordinated execution, and evolve the operating model as ITF scales its rare disease portfolio. It requires strength in strategy, execution, and organizational effectiveness, including the ability to frame ambiguous problems, influence senior leaders, navigate a global/local matrix, and move between enterprise strategy and hands-on execution. The Chief of Staff works across functions without displacing functional ownership, particularly where issues cross organizational boundaries, ownership is unclear, or additional enterprise leadership is needed. The position owns enterprise planning and performance processes, cross-functional initiatives, leadership operating rhythms, governance, Board and Joint Steering Committee preparation, and coordination between ITF Therapeutics and Italfarmaco. It also supports the President’s strategic communications and represents the President when appropriate.

Requirements

Bachelor's degree required.
12+ years of relevant experience in biotechnology/pharmaceuticals, management consulting, strategy, business operations, program/portfolio leadership, or related roles, including significant experience operating with senior executives.
Demonstrated experience operating at the executive and Board level.
Track record designing and running planning and governance processes in a scaling organization.
Exceptional executive communication skills, including executive-level writing and the ability to independently produce Board-ready materials.
Strong analytical and strategic thinking skills, with the ability to simplify complexity.
Demonstrated ability to influence and collaborate across diverse teams without formal authority.
Passion for rare disease innovation and patient impact.

Nice To Haves

Advanced degree in business, life sciences, or a related field (MBA, PharmD, PhD, MPH, or equivalent).
Experience operating within a global matrix, ideally with a non-US parent company or global function.
Commercial-stage pharmaceutical experience, including product launch.
Prior Chief of Staff, business operations, or portfolio management experience.
Management consulting experience.

Responsibilities

Serve as a strategic thought partner and sounding board to the President, bringing an independent perspective and framing key strategic and operating questions.
Identify, structure, and drive resolution of complex or ambiguous enterprise issues, developing options, trade-offs, and recommendations.
Prepare the President for high-stakes internal and external engagements, including Board meetings, leadership discussions, and organizational communications.
Partner with the President on enterprise communications, translating strategy, decisions, and priorities into clear narratives for employees, leadership, the Board, and global stakeholders.
Model company values and champion transparency, accountability, and patient-centered decision-making.
Work with the Group CEO chief of staff to coordinate key business processes, stay informed about business issues, and help address opportunities and issues across the organizations.
Design and execute long-range planning, annual strategic planning, and the Annual Operating Plan.
Lead enterprise goal setting and translate strategy into focused priorities for leadership and organizational execution.
Ensure functional plans align with enterprise priorities and surface gaps, dependencies, and conflicts early.
Partner with finance and functional leaders to integrate strategic priorities, resource needs, and financial constraints into enterprise planning; surface trade-offs and ensure agreed resource decisions are reflected in operating plans.
Own the enterprise business performance framework and review cadence, defining critical measures with business and functional leaders and ensuring consistent, decision-useful reporting.
Lead high-priority enterprise initiatives that span functions, involve significant ambiguity, or require additional enterprise leadership.
Structure complex cross-functional work into objectives, workplans, decisions, dependencies, and accountabilities, and drive execution through completion.
Identify inefficient or ineffective ways of working as the company scales and drive solutions, coordinating with the Group CEO chief of staff where processes extend beyond the US environment.
Establish permanent ownership and operating mechanisms for initiatives as they mature and transition into the organization.
Own the leadership team operating rhythm, including agendas, pre-reads, facilitation, decision capture, and follow-through.
Design and evolve the enterprise governance model, including forums, accountabilities, decision rights, participants, and escalation paths.
Prepare the President and leadership team for Board and Joint Steering Committee meetings, owning materials, narratives, and stakeholder pre-alignment.
Ensure leadership forums are decision-oriented, with clear decision rights, high-quality pre-work, recommendations, and follow-through.
Lead leadership team offsites from objectives and design through facilitation and outputs.
Establish and maintain enterprise standards, templates, and operating mechanisms, simplifying or retiring them when they no longer add value.
Partner with the President and leadership team to evolve the operating model, clarifying roles, interfaces, decision rights, and accountabilities as the organization and portfolio grow.
Serve as an operating link between ITF Therapeutics and Italfarmaco, driving alignment across US and corporate priorities, planning, governance, reporting, and decision-making.
Represent the President, as appropriate, with the leadership team, functional leaders, and external stakeholders, accurately conveying the President’s intent.
Build trusted relationships across functions and facilitate alignment among stakeholders with differing priorities, perspectives, or incentives.
Connect work across functions without displacing functional accountability, helping leaders resolve dependencies and make enterprise-oriented decisions.