Chemist II - Oligo Plate Synthesis
About The Position
The Chemist II is responsible for the synthesis and downstream processing of plate-based oligonucleotides. The role involves maintaining synthesizers, executing synthesis, analyzing products via LC-MS, formulating oligonucleotides for delivery to biologists using a liquid handler, and performing quality-control checks on final delivery plates. The Chemist II works on multiple projects simultaneously and stays current with new oligonucleotide modifications. The position supports ongoing projects in collaboration with senior chemists and other team members. It also includes maintaining the laboratory, documenting work in electronic laboratory notebooks, following company and client quality, health, safety, security, and environmental policies, and complying with applicable management systems and regulatory requirements. Other duties may be assigned by the Manager according to department needs and workload. The position is based in Boston, Massachusetts. Hours are typically Monday through Friday, 40 hours per week, with flexibility required to meet department needs and complete assigned projects. Compensation is listed as $36.00–$40.00 per hour; actual compensation may vary based on factors including location, education, experience, and skillset.
Requirements
- Strong laboratory skills and knowledge of basic laboratory techniques and equipment, including pipetting, mass spectrometry, and chromatography.
- Basic understanding of chemistry, stoichiometry, and chemical synthesis.
- Strong organizational and time-management skills.
- Effective communication skills for collaboration and clearly conveying technical information.
- Strong problem-solving abilities and critical-thinking skills.
- Ability to organize and prioritize workload to meet or exceed deadlines.
- Ability to work individually and as part of a team.
- Proficiency with Windows, Word, and Excel.
- Strong attention to detail and ability to follow protocols precisely.
- Positive attitude, self-motivation, and a high level of engagement.
- Eagerness to learn and adapt in a fast-paced environment.
- Ability to champion and adhere to company values, including team engagement.
Nice To Haves
- Hands-on experience in solid-phase oligonucleotide synthesis.
- Experience with analytical instrumentation such as Agilent LC-MS and UPLC, or Vanquish LTQ.
Responsibilities
- Assist with oligonucleotide synthesis using automated 786 synthesizers, following established protocols and ensuring accurate reagent preparation and reaction conditions.
- Purify oligonucleotides when needed using techniques such as FPLC or cartridge-based purification.
- Conduct analytical assays, including LC-MS, to verify the quality and identity of synthesized oligonucleotides.
- Maintain accurate, detailed records of experiments, procedures, and results in electronic laboratory notebooks, in compliance with company standards and regulatory requirements.
- Contribute to laboratory maintenance.
- Collaborate with senior chemists and other team members to support ongoing projects.
- Use general laboratory equipment, including pipettors, Nanodrops, centrifuges, and balances.
- Use instrument-specific software and other software systems, including Microsoft Office, LIMS, and electronic laboratory notebooks, to capture and analyze data.
- Identify and troubleshoot technical issues and suggest solutions to clients and management.
- Follow client and company Quality, Health, Safety, Security, and Environmental policies and procedures.
- Comply with client and company management systems and applicable regulatory requirements.
- Perform other duties as assigned by the Manager based on department needs and workload.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
No Education Listed
