Chemist II - Oligo Plate Synthesis
About The Position
The Chemist II is responsible for synthesizing and downstream processing plate-based oligonucleotides. The role includes maintaining synthesizers, executing synthesis, analyzing products via LC-MS, formulating oligonucleotides for delivery to biologists using a liquid handler, and performing quality-control checks on final delivery plates. The Chemist II works on multiple projects simultaneously and stays current with new oligonucleotide modifications. The position supports oligonucleotide synthesis, purification, analysis, laboratory maintenance, and project collaboration. It also involves maintaining accurate electronic laboratory notebook records, following company and client quality, health, safety, security, environmental, and regulatory requirements, and identifying and troubleshooting technical issues for clients and management. Other duties may be assigned according to the Manager, department needs, and workload. Hours are typically Monday through Friday, 40 hours per week, with flexibility required to meet departmental needs and complete other projects. The role is based in Boston, Massachusetts, and reports to a Manager. Compensation is $36.00–$40.00 per hour.
Requirements
- Bachelor’s degree in Chemistry, Chemical or Biomedical Engineering, Pharmaceutical Sciences, or a related field, with 1–2 years of experience; or a Master’s degree with 0–1 year of experience.
- Strong laboratory skills and knowledge of basic laboratory techniques and equipment, including pipetting, mass spectrometry, and chromatography.
- Basic understanding of chemistry, stoichiometry, and chemical synthesis.
- Strong organizational and time-management skills.
- Effective communication skills for collaborating with team members and conveying technical information clearly.
- Strong problem-solving abilities and critical-thinking skills.
- Ability to organize and prioritize workload to meet or exceed deadlines.
- Ability to work independently and as part of a team.
- Proficiency with Windows, Word, and Excel.
- Strong attention to detail and ability to follow protocols precisely.
- Positive attitude, self-motivation, and a high level of engagement.
- Eagerness to learn and adapt in a fast-paced environment.
- Commitment to company values, including team engagement.
Nice To Haves
- Hands-on experience in solid-phase oligonucleotide synthesis.
- Experience with analytical instrumentation such as Agilent LC-MS and UPLC or Vanquish LTQ.
Responsibilities
- Assist with oligonucleotide synthesis using automated 786 synthesizers, following established protocols and ensuring accuracy in reagent preparation and reaction conditions.
- Purify oligonucleotides as needed using techniques such as FPLC or cartridge-based purification.
- Conduct analytical assays, including LC-MS, to verify the quality and identity of synthesized oligonucleotides.
- Maintain accurate and detailed experiment, procedure, and result records using electronic laboratory notebooks, in compliance with company standards and regulatory requirements.
- Contribute to laboratory maintenance.
- Collaborate with senior chemists and other team members to support ongoing projects.
- Use general laboratory equipment, including pipettors, nanodrops, centrifuges, and balances.
- Use instrument-specific data capture and analysis software, Microsoft Office applications, LIMS, and electronic laboratory notebooks.
- Identify and troubleshoot technical issues and suggest solutions to clients and management.
- Follow client guidelines and company Quality, Health, Safety, Security, and Environmental policies and procedures.
- Comply with client and company management systems and applicable regulatory requirements.
- Perform other duties assigned by the Manager based on department needs and workload.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
