Chemist II
About The Position
The Chemist II is responsible for assisting with the synthesis and downstream processing of oligonucleotides using various analytical techniques. The role uses Dr. Oligo and MerMade 192 oligosynthesizers, AKTA, LC-MS, UPLC, LTQ, and QDA analytical instruments for purification and analysis, and a Lynx liquid handler for downstream automation. The Chemist II works on multiple projects simultaneously, helps train new staff, and stays current with new oligonucleotide modifications. The position typically works Monday through Friday for 40 hours per week, with flexibility required to meet departmental needs and complete other assigned projects. The role is based in Indianapolis, Indiana, within Consumer Products Services/ATL, and reports to the Manager.
Requirements
- Bachelor’s degree in Chemistry, Biochemistry, or a closely related field.
- At least one year of experience with oligonucleotide chemistry or plate-based automation development.
- Experience troubleshooting and optimizing synthetic protocols on various synthesizers.
- Experience with automation instruments such as Tecan, Lynx, Dispendix, Hamilton, or Beckman.
- Strong laboratory skills and experience with analytical instrumentation such as AKTA, Agilent LC-MS and UPLC, Vanquish LTQ, or Waters QDA.
- Laboratory experience with solution preparation, separation, quantification, and synthesis methodologies for DNA/RNA, proteins, oligonucleotides, or related materials.
- Familiarity with statistical analysis tools and ability to solve technical problems and recommend improvements.
- Strong organizational skills and ability to prepare written technical reports.
- Strong oral communication skills, including presenting facts and recommendations and communicating effectively in groups with colleagues and clients.
- Ability to perform multiple tasks and organize and prioritize workload to meet or exceed deadlines.
- Ability to work individually and as part of a team.
- Proficiency with Windows, Word, and Excel.
- Attention to detail, a positive attitude, self-motivation, and a high level of engagement.
- Adherence to company values and commitment to team engagement.
- An equivalent combination of education and experience may be accepted in lieu of the stated degree and experience requirements.
Responsibilities
- Independently perform oligonucleotide synthesis and downstream processing, including cleavage, deprotection, purification, desalting, and annealing.
- Perform bioconjugation of single-strand oligonucleotides.
- Use general laboratory equipment and analytical instruments for synthesis, methods, and analysis.
- Work with the RNAi plate synthesis team to understand and validate synthesis and downstream-processing requirements.
- Review literature to stay current on oligonucleotide methods and provide technical solutions to clients and management.
- Maintain detailed records of daily experiments in electronic laboratory notebooks.
- Perform general laboratory maintenance.
- Train new staff members.
- Identify and troubleshoot technical issues and suggest solutions to clients and management.
- Follow client and company Quality, Health, Safety, Security, and Environmental policies and procedures, and comply with applicable management systems and regulatory requirements.
- Perform other tasks, projects, and responsibilities as required by the Manager, department needs, and workload.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
