Flagship Labs 111: Cell Biology Co-Op

Flagship Pioneering•Cambridge, MA

About The Position

Flagship Labs 111 Inc. (FL111) is a privately held, early-stage biotechnology company pioneering a novel platform harnessing innovations in chemistry, computation, and data science to create new therapeutic modalities beyond traditional small molecules. FL111 is backed by Flagship Pioneering, bringing the courage, vision, and resources to guide FL111 from platform validation to patient impact. We are seeking collaborative, creative and relentless problem solvers that share our passion for impact to join us!

Requirements

Pursuing a BS or MS in Biology, Cell Biology, Molecular Biology, Biochemistry, Biomedical Sciences, or related field.
Hands-on mammalian cell culture experience, ideally with cancer cell lines.
Experience running controlled cell-based experiments with small-molecule compound treatment.
Hands-on experience with at least one of: Western blotting, qPCR, ELISA, cell proliferation/viability assays.
Working knowledge of experimental controls, replicates, dilution calculations, and basic quantitative analysis.
Strong attention to detail and commitment to reproducible, high-quality data.
Ability to follow and write protocols, and maintain accurate documentation.
Ability to work independently at the bench while flagging observations, unexpected results, and uncertainties promptly.
Strong organizational and communication skills; comfortable in a multidisciplinary research environment.

Nice To Haves

Prior industry, academic, or co-op experience with cancer cell models.
Experience with concentration-response and time-course experiments.
Experience generating and interpreting dose-response curves and PD datasets.
GraphPad Prism or similar software experience.
Familiarity with oncology drug discovery, targeted therapies, or heterobifunctional molecules.
Experience troubleshooting and optimizing cell-based assays.

Responsibilities

Design and execute cell-based experiments characterizing novel heterobifunctional molecules in cancer cell models.
Maintain, expand, and qualify a panel of cancer cell lines for ongoing studies.
Plan and run compound treatment experiments, including concentration-response, time-course, and combination studies.
Execute cell proliferation and viability assays to evaluate cellular response to treatment.
Perform Western blotting, qPCR, ELISA, and other cell-based PD assays to assess target engagement, pathway modulation, and downstream molecular effects.
Analyze data, generate figures and summaries, and interpret results against experimental hypotheses.
Review results with the team; help identify follow-up experiments, controls, and troubleshooting steps.
Develop, optimize, and document protocols to support reproducible execution across studies.
Maintain complete, accurate records in an electronic lab notebook (ELN) — conditions, calculations, observations, deviations, raw data, and conclusions.
Present findings to scientists and project teams; collaborate with biology and chemistry colleagues on experimental planning and molecule characterization.