Tilde Bio: Bioconjugation Chemistry Co-Op

Flagship Pioneering Co-Op Program • Cambridge, MA

7h • $25 - $35 • Onsite

About The Position

Tilde Bio is seeking a motivated Master’s-level Co-Op to join its Bioconjugation Chemistry team and develop novel bioconjugation chemistries for site-selective protein modification. The Co-Op will design, synthesize, and evaluate reactive handles and conjugation strategies, applying them to proteins with small molecules, linkers, payloads, and other functional moieties. The role carries synthesized reagents through protein conjugation and characterization to expand the toolkit for building next-generation protein conjugates. It is a hands-on laboratory position with scientific ownership, working closely with chemists, protein engineers, and nanopore scientists.

The position is open exclusively to current Northeastern University Co-Op students. The work period is January 2027 to June 2027, full-time at 40 hours per week, with five days in the office. The position is a short-term engagement and is not eligible for health and welfare benefits. Retirement benefits may be available after completing a set number of hours. The pay range is $25–$35 per hour.

Requirements

• Currently pursuing an M.S. in Chemistry, Chemical Biology, Biochemistry, or a closely related field.
• Strong foundation in organic synthesis, including multistep synthesis, purification, and characterization.
• Hands-on experience with analytical techniques such as NMR and LC-MS, and ability to extract structural information from spectra.
• Working knowledge of protein chemistry, including handling, purification, and buffer considerations.
• Previous research or industry experience in bioconjugation, chemical biology, or protein modification, and familiarity with antibody or protein conjugate modalities.
• Ability to work independently, troubleshoot experiments, and think critically about results.
• Strong written and verbal communication skills and a collaborative mindset.
• Must be a current Northeastern University Co-Op student.

Responsibilities

• Design and execute experiments to discover and optimize bioconjugation reactions on proteins and peptides, targeting native residues, termini, and/or genetically encoded or non-canonical handles.
• Synthesize small-molecule reagents, linkers, and probes, including their purification and structural characterization.
• Screen reaction conditions under biocompatible conditions and assess kinetics, selectivity, and yield.
• Characterize protein conjugates using intact-protein LC-MS and related methods to determine purity, conjugation efficiency, and site selectivity.
• Evaluate conjugate stability and the impact of modification on protein structure and function.
• Maintain accurate, detailed records in an electronic lab notebook.
• Analyze data, summarize findings, and present results at team meetings.
• Contribute to a culture of safe laboratory practice and scientific rigor.

Benefits

• Access to enrichment sessions, a dedicated professional development track, and a mentor through the Flagship Pioneering Co-Op Program.
• Strong Co-Ops may be considered for future opportunities across Flagship and its portfolio companies.
• Retirement benefits may be available after completing a set number of hours.

What This Job Offers

• Job Type: Full-time
• Career Level: Intern