Associate Scientist - Escoubas Laboratory - Center of Excellence in Neuro-Oncology Sciences (CENOS)
About The Position
The Escoubas Laboratory, within the Center of Excellence in Neuro-Oncology Sciences (CENOS) at St. Jude Children’s Research Hospital, is seeking a highly motivated Associate Scientist to join our growing research team. CENOS fosters a highly collaborative and innovative research environment dedicated to advancing discoveries that improve outcomes for children with brain tumors. The Escoubas Lab investigates bidirectional communication between neurons and microglia through nucleic acid sensing pathways, with implications for neurodevelopment, neurological disease, and pediatric brain tumors. This position is ideal for a candidate with a strong background in experimental neuroscience, immunology, or neuroimmunology, and hands-on experience with brain tumor models, histology, and imaging techniques. The successful candidate will have demonstrated expertise in in vivo experimental methods, including stereotaxic and intracerebroventricular (ICV) injections, transcardial perfusion, tissue collection and processing, immunofluorescence staining, and confocal microscopy. Experience with primary neural cell culture (microglia, neurons, and astrocytes) and preclinical research resources is highly desirable. The individual selected for this role will be expected to work collaboratively within a multidisciplinary research environment, drive projects toward publication, and contribute to the establishment and optimization of laboratory protocols as the lab continues to expand.
Requirements
- Bachelor’s degree in a relevant scientific area
- 7 + years of research experience is required
- 5 + years of research experience is required with a Master’s degree
- 2 + years of research experience is required with a PHD
- Demonstrated expertise in in vivo experimental methods, including stereotaxic and intracerebroventricular (ICV) injections, transcardial perfusion, tissue collection and processing, immunofluorescence staining, and confocal microscopy.
- Strong background in experimental neuroscience, immunology, or neuroimmunology
- Hands-on experience with brain tumor models, histology, and imaging techniques
Nice To Haves
- Experience with primary neural cell culture (microglia, neurons, and astrocytes)
- Experience with preclinical research resources
- Experience leading and supporting research experiments
- Some experience leading lab and scientific project coordination, maintenance, and other research support activities
- Experience in guiding and training other laboratory personnel
- Proven performance in earlier role/comparable role
Responsibilities
- Conduct in vivo studies using preclinical research models, including intracerebroventricular (ICV) injections, behavioral assessments, transcardial perfusion, tissue collection, and downstream analyses.
- Process brain tissue for histological evaluation, including cryosectioning, immunofluorescence staining, and confocal microscopy.
- Culture and maintain primary neural cell populations (including microglia, neurons, and astrocytes) as well as established cell lines to support in vitro research studies.
- Analyze, quantify, and interpret experimental and imaging data while maintaining detailed and accurate records of methods, results, and study outcomes.
- Coordinate and maintain preclinical research resources, including genotyping workflows, research support activities, and associated record keeping.
- Collaborate effectively with laboratory members, institutional core facilities, and research colleagues across departments.
- Contribute to manuscript preparation, data presentation, and dissemination of research findings.
- Assist in the development, optimization, and standardization of laboratory procedures and protocols.
- Perform other duties as assigned in support of the scientific goals of the laboratory and institution.
Benefits
- St. Jude is an Equal Opportunity Employer
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
