Associate Scientist (Dr. Blanchard Lab) - Stem Cell Biology and Regenerative Medicine

Mount Sinai Health Systems•New York, NY

1d•$58,661 - $98,979

About The Position

The Blanchard Laboratory at the Icahn School of Medicine at Mount Sinai seeks a skilled, creative, and motivated scientist to study how genetic and environmental factors shape the human brain’s vulnerability to neurodegenerative disease. The lab investigates cellular and molecular mechanisms of Alzheimer’s disease and related disorders to identify potential therapeutic strategies. It develops and applies human induced pluripotent stem cell (iPSC)-based brain models, including multicellular organoids and assembloids, integrated with genomic, computational, and systems-level approaches. Research uses human iPSC models, post-mortem human brain analysis, and mouse models to support mechanistic discoveries and translational research. Research areas include Alzheimer’s genetic risk mechanisms such as APOE biology; neurovascular and glial contributions to neurodegeneration; lipid metabolism and metabolic stress in the aging brain; human brain organoid and assembloid engineering; and multi-omics analysis of human brain tissue and disease models. The position is based in the Nash Family Department of Neuroscience at the Icahn School of Medicine at Mount Sinai. The lab offers mentorship, career-development opportunities, and an intellectually stimulating research environment.

Requirements

Ph.D. in Biological Science or a related field.
Three years of experience.

Nice To Haves

iPSC cell culture and differentiation.
Molecular and cell biology.
CRISPR, bioengineering, and confocal microscopy.
Calcium imaging and optogenetics.
Mouse models.
Computational biology and single-cell/single-nuclei RNA sequencing.
Ph.D. with five years of experience.

Responsibilities

Conduct research to develop methodologies, instrumentation, and procedures for medical application; analyze data and present findings.
Design and conduct complex clinical research studies, evaluating alternative methods, computational modeling, diagnosis, and treatment.
Plan and direct studies investigating human or animal disease, preventive methods, and disease treatments.
May assist in clinical laboratory operations.
Follow strict safety procedures when handling materials to avoid contamination.
Teach principles of medicine and medical and laboratory procedures to physicians, residents, students, and research staff.
Confer with health departments, industry personnel, physicians, and others to develop health safety standards and public health improvement programs.
Develop treatments and design research tools and techniques.
Explore subject areas and define the scope and selection of problems for investigation through conceptually related studies.
Develop hypotheses and methodology for evaluating results.
Examine clinical trial results and adjust dosage levels to reduce negative side effects or improve results.
Communicate research results to the scientific community through published papers.
Develop research proposals and obtain support for new or continuing research activities.
Make recommendations that have a major impact on extensive scientific research activities.
Perform other related duties.