Associate Scientist (Dr. Blanchard Lab) - Stem Cell Biology and Regenerative Medicine

Mount Sinai Health System•New York, NY

About The Position

The Blanchard Laboratory at the Icahn School of Medicine at Mount Sinai is seeking a skilled, creative, and motivated scientist to study how genetic and environmental factors shape the human brain’s vulnerability to neurodegenerative disease. The laboratory investigates cellular and molecular mechanisms underlying Alzheimer’s disease and related disorders, with the goal of identifying therapeutic strategies. Research uses advanced human iPSC-based brain models, including multicellular organoid and assembloid systems, alongside genomic, computational, and systems-level approaches. Projects span Alzheimer’s genetic risk mechanisms such as APOE biology; neurovascular and glial contributions to neurodegeneration; lipid metabolism and metabolic stress in the aging brain; human brain organoid and assembloid engineering; and multi-omics analysis of human brain tissue and disease models. Experimental platforms also include post-mortem human brain analysis and mouse models. The laboratory is part of the Nash Family Department of Neuroscience at the Icahn School of Medicine at Mount Sinai. The environment offers access to core facilities and collaborative opportunities across neuroscience, genomics, stem cell biology, and translational medicine, as well as mentorship and career development opportunities.

Requirements

Ph.D. in Biological Science or a related field.
Three years of experience.

Nice To Haves

iPSC cell culture and differentiation.
Molecular and cell biology.
CRISPR and bioengineering.
Confocal microscopy.
Calcium imaging and optogenetics.
Mouse models.
Computational biology and single-cell/nuclei RNA-seq.
Ph.D. with five years of experience.

Responsibilities

Conduct research to develop methodologies, instrumentation, and procedures for medical application; analyze data and present findings.
Design and conduct complex clinical research studies, evaluating alternative methods, computational modeling, diagnosis, and treatment.
Plan and direct studies investigating human or animal disease, preventive methods, and treatments.
May assist in clinical laboratory operations.
Follow strict safety procedures when handling materials to avoid contamination.
Teach principles of medicine and medical and laboratory procedures to physicians, residents, students, and research staff.
Confer with health departments, industry personnel, physicians, and others to develop health safety standards and public health improvement programs.
Develop treatments and design research tools and techniques.
Explore subject areas and define the scope and selection of problems for investigation through conceptually related studies.
Develop hypotheses and methodologies for evaluating results.
Examine clinical trial results and adjust dosage levels to reduce negative side effects or improve results.
Communicate research results to the scientific community through published papers.
Develop new research proposals and obtain support for new or continuing research activities.
Make recommendations that have a major impact on extensive scientific research activities.
Perform other related duties.