Associate Scientist (Dr. Blanchard Lab) - Stem Cell Biology and Regenerative Medicine

Mount Sinai Health System•New York, NY

About The Position

The Blanchard Laboratory seeks a highly skilled, creative, and motivated scientist to study how genetic and environmental factors shape the human brain’s vulnerability to neurodegenerative disease. The laboratory investigates cellular and molecular mechanisms underlying Alzheimer’s disease and related disorders, with the goal of identifying new therapeutic strategies. It develops and applies human iPSC-based brain models, including multicellular organoid and assembloid systems, integrating them with genomic, computational, and systems-level approaches to examine how genetic risk factors and environmental exposures drive disease processes. Research areas include genetic risk mechanisms in Alzheimer’s disease, such as APOE biology; neurovascular and glial contributions to neurodegeneration; lipid metabolism and metabolic stress in the aging brain; human brain organoid and assembloid engineering; and multi-omics analysis of human brain tissue and disease models. Experimental platforms combine human iPSC models, post-mortem human brain analysis, and mouse models to support mechanistic discoveries relevant to translational research. The laboratory is in the Nash Family Department of Neuroscience at the Icahn School of Medicine at Mount Sinai. The position offers an intellectually stimulating environment, strong mentorship, career-development opportunities, and work at the forefront of human brain modeling and neurodegenerative disease research.

Requirements

Ph.D. in Biological Science or a related field.
Three years of experience.

Nice To Haves

iPSC cell culture and differentiation.
Molecular and cell biology.
CRISPR, bioengineering, and confocal microscopy.
Calcium imaging and optogenetics.
Mouse models.
Computational biology and single-cell/nuclei RNA sequencing.
Ph.D. with five years of experience.

Responsibilities

Conduct research to develop methodologies, instrumentation, and procedures for medical application; analyze data and present findings.
Design and conduct complex clinical research studies requiring evaluation of alternative methods, computational modeling, diagnosis, and treatment.
Plan and direct studies investigating human or animal disease, preventive methods, and disease treatments.
May assist in clinical laboratory operations.
Follow strict safety procedures when handling materials to avoid contamination.
Teach principles of medicine and medical and laboratory procedures to physicians, residents, students, and research staff.
Confer with health departments, industry personnel, physicians, and others to develop health safety standards and public health improvement programs.
Develop treatments and design research tools and techniques.
Explore subject areas and define the scope and selection of problems for investigation through conceptually related studies.
Develop hypotheses to be tested and methodologies for evaluating results.
Examine clinical trial results and adjust dosage levels to reduce negative side effects or improve results.
Communicate research results to the scientific community through published papers.
Develop new research proposals and obtain support for new or continuing research activities.
Make recommendations that have a major impact on extensive scientific research activities.
Perform other related duties.