Associate Scientist II, Bioassays
About The Position
Arrowhead Pharmaceuticals, Inc. is a commercial stage biopharmaceutical company focused on developing medicines that treat intractable diseases by silencing the genes that cause them. They utilize a broad portfolio of RNA chemistries and efficient modes of delivery to trigger the RNA interference (RNAi) mechanism for rapid, deep, and durable knockdown of target genes. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. The company is dedicated to developing innovative drugs for diseases with a genetic basis, often characterized by the overproduction of disease-involved proteins. Their RNAi technologies have the potential to address conditions in virtually any therapeutic area and pursue disease targets not addressable by small molecules and biologics. Arrowhead is a leader in bringing RNAi to diseases outside the liver, with a clinical pipeline targeting liver and lung diseases and a promising preclinical pipeline. The company has corporate headquarters in Pasadena, CA, with R&D teams in Madison, WI & San Diego, CA, and a manufacturing facility in Verona, WI. Their employees are described as nimble, science-driven innovators collaborating to bring new therapies to patients. Arrowhead is seeking a highly motivated molecular biologist to join their growing Molecular Biology team at their Madison site. This team supports R&D projects across all sites. The ideal candidate will have 1-2 years of cloning experience and the ability to independently manage multiple constructs simultaneously.
Requirements
- Bachelor of Science in Biology or related field
- 3+ years of experience in cell biology, molecular biology, immunology, pharmacology or a related field of biology
- Experience in standard cellular and molecular biology techniques (PCR, Digestion, Ligation, Transformation, DNA isolation)
- Experience in standard microbiology techniques (Bacterial cultures, Autoclaving, Preparing Media)
- Experience in standard cell culture techniques (passaging, transfection)
- Demonstrated innovation, creativity and resilience in problem solving
- Excellent oral and written communication skills
- Self-motivated team player with the ability to thrive in a fast paced, multi-disciplinary, matrixed environment
- Current, valid authorization to work in the country where this role is located
Nice To Haves
- Snapgene and Benchling experience preferred
- 2+ years experience with methods and technologies involving plasmid cloning, AAV packaging, protein expression vectors, microbiology including bacterial cultures and autoclaving, cell culture including transfections and cell line maintenance
- Prior experience with Benchling and Snapgene
Responsibilities
- Support in vitro, ex vivo and/or in vivo studies to facilitate drug discovery and development with some independence
- Propose methods and ways to optimize cloning
- Occasionally present research findings to project teams
- Occasionally read relevant scientific literature and propose applications to projects to troubleshoot and solve problems
- Maintain a high level of productivity and quality in the lab
- Perform critical experiments
- Clone plasmid constructs by various methods (Digest/ligation, IVA)
- Perform large-scale plasmid preps
- Autoclave glassware and media
- Manage lab inventory and assist in ordering
- Project documentation
- Work with a small team of scientists, while working closely with other research groups and senior managers
Benefits
- competitive salaries
- excellent benefit package
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
