Associate Director, Proteomics

Inotiv•Nashville, TN

56d•Onsite

About The Position

Proteomics has emerged as a critical discipline driving contemporary drug discovery and clinical pharmacology; once reserved as a support function to biochemistry organizations, proteomics is now an integral part of the drug discovery engine and has merged into a concerted discipline-team alongside pharmacology and molecular pathology. We're looking for a scientific leader who sees the same mission of proteomics and wants to shape its future while enabling a vision set in motion by the Discovery & Translational Sciences Division of Inotiv. As Sr. Principal Scientist, Proteomics, you'll set the scientific direction for how proteomic data shapes biomarker discovery and translational pharmacology across some of the industry's most complex drug discovery & development programs. You'll operate at the intersection of deep technical expertise and high-stakes strategic influence — equally comfortable at the bench, in front of a sponsor's leadership team, or shaping the next phase of our platform roadmap. This is a role for a scientist-leader who wants their proteomics expertise to directly impact on our clients’ drug discovery success.

Requirements

PhD in Chemistry, Biochemistry, or a related field, with postdoctoral training and 5-7+ years of qualified experience in mass spectrometry-based proteomics.
Prior management experience required.
Hands-on expertise with targeted and global/discovery proteomic workflows, including operation and maintenance of current MS instrumentation, especially high-resolution LC-MS/MS, for peptide and protein analysis.
Knowledge of protein/peptide separation, digestion, and enrichment techniques (e.g., immunoaffinity capture, fractionation, high-abundance protein depletion) and chromatographic systems used for proteomic analysis.
Proficiency with proteomic data analysis and bioinformatics software (e.g., Skyline, FragPipe, Proteome Discoverer, DIA-NN) for protein and peptide identification, quantitation, and biomarker analysis of proteomic data.
Detailed understanding of bioanalytical processes, including sample preparation, calibration, quality control, instrument operation/troubleshooting, method development, data processing, and reporting.
In-depth knowledge of analytical testing needed in drug discovery, biomarker verification, and/or clinical or translational proteomics.
Demonstrated ability to develop creative, cross-functional approaches to apply proteomics techniques to client and program needs.
Understanding of GMP/GLP/GCP regulations with the ability to apply these practices daily, including the responsibilities of a GLP Principal Investigator.
Scientific writing experience for reports and manuscripts; peer-reviewed publications, posters, or presentations in proteomics/MS preferred.
Results Driven. Drives efficiently and accurately toward results, setting high but achievable standards and continually seeking process improvements.
Efficient. Takes ownership of time and effectiveness, acting proactively and working through challenges with minimal direction.
Communication. Communicates complex information clearly and articulately, in oral and written form, tailored to audience and purpose.
Collaboration. Actively supports team success, shares information, and gets things done with and through others.
Critical Thinking and Problem Solving. Identifies key components of problems, interprets information from varied sources, and generates and evaluates creative solutions.
Organization and Time Management. Plans and prioritizes work, manages time to meet deadlines, and follows through on commitments.

Nice To Haves

postdoctoral training

Responsibilities

Serve as an interdisciplinary scientific lead for proteomics within DTS, building an integrated drug discovery partnership across In Vivo Pharmacology, Molecular/Cellular Pharmacology, and Investigative & Molecular Pathology to advance biomarker discovery, target validation, and translational research programs.
Drive proteomics platform strategy to strengthen market position, including technology selection, contemporizing of mass spectrometry-based analysis platforms, and biomarker-based expression profiling in partnership with Molecular Pathology.
Serve as Inotiv's primary scientific point of contact for Study Directors and Sponsors on targeted and global proteomics bioanalytical projects, from discovery through clinical development, and represent Inotiv's proteomics capabilities through commercial strategy support, scientific posters, publications, and presentations.
Lead experimental design and conduct of targeted and global/discovery proteomics studies, ensuring compliance with established best practices and SOPs.
Lead proteomics platform development and optimization: method development and validation (GxP and non-GxP), sample-preparation workflows (protein digestion, immunoaffinity enrichment, high-abundance protein depletion, phospho-proteomics), instrumentation, chromatography, and automation.
Direct bioinformatic and statistical analysis of proteomic datasets (e.g., Skyline, FragPipe, Proteome Discoverer) to identify, quantify, and interpret protein and peptide biomarkers, and identify opportunities to apply MS proteomics platforms to critical client and company needs as a recognized thought leader.
Develop and maintain SOPs for proteomic sample preparation, LC-MS/MS method development, and data analysis; review literature and emerging technologies to guide platform decisions.
Maintain broad familiarity with Inotiv's capabilities, with particular expertise in Nashville, to provide timely scientific answers to prospective clients; perform quality control review of data and reports; troubleshoot and resolve method and assay challenges.
Train and mentor colleagues to build proteomics, mass spectrometry, and analytical expertise.
Ensure GLP/SOP compliance as a GLP Principal Investigator, including timely reporting of deviations, proper documentation, and archival of study data and samples.
Coordinate with study management and operations teams to maintain project visibility and support customer satisfaction from initiation through completion.
Uphold Inotiv Core Values, safety regulations, and confidentiality standards, and interact professionally with clients, colleagues, and the community.
Demonstrate ability to manage scientific, operational, and administrative aspects of the proteomics team.
Responsible for the development and training of employees to meet current and future business needs.
Provide regular coaching and feedback to team members.
Conduct interviews and initiate hiring requests for team when needed.
Provide an environment which encourages the company’s commitment to equal employment opportunities and the value of a diverse workforce.