Requirements for In Vitro Associate Principal Scientist/Pharmacology

  • PhD + 8+ years (can include postdoc experience), in pharmacology, or related discipline (must have a minimum of 2+ years industry leading early discovery projects to IND, functional lead experience acceptable)
  • Proficient in experimental biological techniques such as immunoassays (ELISA, MSD, Luminex), qPCR, biochemical assays, enzyme kinetics, Western Blot, RNA extractions, etc.
  • Working knowledge of cell cultures, including mammalian cell culture
  • Compound screening experience
  • Experience with neuroscience is a plus
  • Developed novel complex model systems (didn't just purchase off the shelf)
  • Transcriptomics (RNA extractions, library prep), experience with NGS is a plus

Responsibilities for In Vitro Associate Principal Scientist/Pharmacology

  • Lead the in-vitro pharmacology team, working across programs to enable characterization and screening of new compounds.
  • Develop and execute in vitro assays to validate compound activity using cell-free and cell-based models.
  • Perform cell cultures and mainteneance of cell lines to be used to evaluate small molecules in high and medium throughput assays.
  • Perform assays to enable chemistry SAR iterations.
  • Screen and test libraries of small molecules in both internal assays and with CROs.
  • Mange CRO relationships to support high-throughput screens.
  • Accurate and organized data entry, analysis, technical report writing, and presentation of experimental results to research groupsIdentification of best model / troubleshooting / leading projects.
  • Select and champion complex, yet robust in vitro model systems for target biology.
  • Manage a direct report to enable high and medium throughput screens to support all drug discovery programs.



*Excellent medical, dental, and vision coverage
*401(k) plan with employer matching for contributions
*Disability insurance, Life insurance, Dependant Care FSA and Healthcare FSA
*Unlimited paid time off
*Paid parental leave
*Access to free onsite fitness center
*Free snacks and lunch for employees who work onsite
*WFH stipend for employees who work remotely

About this position

This job is no longer online. We keep it on here for reference only.

Job Summary

Years of Experience
$131,500 - $156,500
South San Francisco, CA
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Verge Genomics is a next-generation biopharmaceutical start-up using systems biology to accelerate development of life-saving treatments for neurodegenerative diseases. Our platform uses patient genomes, gene expression, and epigenomics to identify new therapeutic gene targets, predict effective drugs, and stratify patient subpopulations for increased clinical success. Verge's approach offers a breakthrough opportunity to identify drugs that dramatically improve patient outcomes and fundamentally lower the cost curve of pharmaceutical development.

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