VP, Head of Cyprotex US ADMET Operations

Evotec•Princeton, NJ

About The Position

Cyprotex, an Evotec company, specializes in ADME-Tox and Biosciences, using in vitro laboratory experiments and in silico computer modelling. Founded in 1999, the company serves pharmaceutical and biotech, cosmetics and personal care, chemicals, academic, and not-for-profit organizations. Cyprotex is seeking an enthusiastic DMPK scientist to lead its US ADME Sciences function. The role manages the scientists and resources providing high-throughput and custom ADME services and provides leadership to Biotransformation and Bioanalysis functions. It leads development of methods and technologies and process improvements to maintain Cyprotex’s reputation in the ADME field. The position works closely with the Director of Scientific Operations and other functional heads as part of the core operational management structure responsible for day-to-day decisions and improvements across Cyprotex in the US. It is based in Princeton, New Jersey.

Requirements

PhD training in ADME sciences from an internationally recognized academic program.
Extensive hands-on experience operating and troubleshooting ADME and/or in vitro safety assays.
Deep experience with LC-MS/MS instrumentation across multiple manufacturers and software applications.
Experience managing, developing, and coaching staff.
Excellent interpersonal skills with laboratory staff, project managers, clients, and senior managers.
Ability to build constructive, effective, and lasting relationships.
Ability to present convincingly and confidently in formal and informal settings.
Proactive and regular communication that keeps internal and external stakeholders updated.
Ability to inspire and enthuse others and act as an open, honest, and cooperative role model.
Ability to manage time effectively and prioritize tasks.
Ability to identify opportunities for improvement.

Nice To Haves

Experience with high-resolution mass spectrometry and high-throughput LC techniques.
Exposure to GC-MS, including method development.
Experience analyzing biotherapeutics.
Experience with metabolite profiling and identification.
Experience in pharmaceutical, biotech, or contract research organizations in analytical method development and/or high-throughput analytics supporting ADME studies.

Responsibilities

Lead the US ADME and Safety Sciences functions and manage personnel and instrumentation resources.
Advance techniques used at Cyprotex and maintain quality and efficiency, ensuring a broad range of chemistries can be assessed, including chemical and personal care ingredients and small-molecule pharmaceutical compounds.
Investigate new instrumentation, assess its suitability for integration into Cyprotex systems, and work with the Information Systems Team to integrate technologies and procedures into the Cyprotex LIMS.
Work with the Head of Global Operations, Cyprotex, and other functional heads to oversee core US operational activities.
Develop the ADME and Safety Sciences functions, advise the Cyprotex Leadership Team where appropriate, and raise the company’s scientific profile by pursuing external presentation opportunities.
Identify opportunities to improve the ADME Sciences function, promote efficiency, and adapt sample-analysis approaches as customer needs change.
Support Business Development with client proposals and relationships, including occasional site visits and teleconferences; contribute to new project plans, including pricing, implementation, and CapEx sourcing.
Oversee staff training and development and provide scientific direction and line management.
Directly manage selected client studies focused on analytical work or using non-standard analytical methods.
Work with UK-based colleagues and the wider Evotec Group to maintain a consistent approach to ADME and in vitro Safety Sciences.