VP, Head of Commercial Operations

Remix Therapeutics•Watertown, MA

About The Position

Patients with adenoid cystic carcinoma (ACC) have waited decades for a treatment option. At Remix Therapeutics, we intend to change that. We are a clinical-stage biopharmaceutical company that has pioneered a new class of small molecule medicines targeting the RNA splicing machinery — correcting the disease-causing errors that drive ACC and other serious conditions at their source. REM-422 is our lead program, currently in clinical evaluation for ACC and AML/HR-MDS, and it is at a critical inflection point. Remix is building the team to bring this novel molecule forward for patients. Position Summary: Remix is seeking an experienced, strategic and hands-on Vice President, Head of Commercial Operations to build and lead the company's Commercial Operations and Business Insights function, initially focused on REM-422. This executive will be accountable for forecasting, market research and competitive intelligence; commercial data and analytics; CRM and field technology; sales operations; incentive compensation; performance reporting; and the external partner ecosystem required to support launch. Reporting to the Chief Commercial Officer and partnering closely with the Head of Sales & Marketing, Head of Market Access, Finance, IT, Legal and Compliance, this leader will translate commercial strategy into disciplined operating plans, high-quality decisions and scalable execution. The successful candidate will pair strategic judgment with analytical depth and a willingness to work directly in the details - from patient-based forecasting and vendor selection to field force design, and dashboard development.

Requirements

Bachelor's degree required; advanced degree in business, science, public health, analytics or a related discipline preferred.
Experience in rare disease, precision oncology, rare solid tumors, hematologic malignancies or another specialty market with concentrated customers and complex patient journeys.
15+ years of progressive biopharmaceutical or biotechnology experience, including substantial leadership responsibility across Commercial Operations, Business Insights, Analytics or related commercialization functions.
Direct experience supporting at least one U.S. product from late-stage development through launch and early commercialization, with meaningful accountability for launch readiness and commercial infrastructure.
Broad, hands-on expertise across forecasting, market research, competitive intelligence, commercial data and analytics, CRM, field operations, incentive compensation and performance reporting.
Demonstrated ability to build or materially scale commercial capabilities in a small or mid-sized biotechnology company operating with limited resources and changing timelines.
Strong patient-based forecasting and scenario-planning skills, with the ability to connect clinical, regulatory, epidemiologic, access and competitive assumptions to enterprise decisions.
Experience selecting and managing commercial data, research, analytics, technology and operations vendors, including budget and performance accountability.
Working knowledge of U.S. healthcare delivery, specialty-product data flows and the legal, compliance, privacy and security requirements governing commercial operations.
Executive presence and communication skills sufficient to influence cross-functional leaders, external partners, the executive team and Board of Directors.
A builder's mindset, strong attention to detail and comfort moving between strategy, analysis and hands-on execution in a fast-changing environment.

Nice To Haves

Experience launching an oral oncology or specialty-pharmacy product and working with specialty pharmacy, distribution, patient services, claims and access data.
Familiarity with ACC, AML, MDS or biomarker-defined oncology populations and the dynamics of academic centers, community oncology and health systems.
Prior experience as an early commercial leader preparing a biotechnology company for its first launch.
Experience building a commercial data architecture and CRM environment from a blank sheet or materially redesigning an existing model.
Experience operating in a public or public-company-ready environment and presenting forecasts, launch readiness or performance recommendations to a Board.

Responsibilities

Set and lead the enterprise commercial insights agenda, integrating primary and secondary market research, epidemiology, patient journey and treatment-flow analysis, market sizing, customer insights and competitive intelligence.
Build, maintain and communicate patient-based forecasts for ACC and future indications; partner with Finance on revenue scenarios, long-range planning and sensitivity analyses.
Translate clinical and regulatory outcomes, target product profile assumptions, biomarker prevalence, treatment patterns, market access dynamics and competitive developments into clear commercial implications.
Develop a sequenced learning plan that addresses the highest-value uncertainties for indication prioritization, positioning, go-to-market design, field planning, access strategy and lifecycle management.
Create compliant mechanisms to capture and synthesize insights from customers, field teams, patient services, payers, external experts and data sources, then convert those insights into decisions and action.
Support portfolio strategy, business development and new-product planning through commercial opportunity assessments, analog analyses and scenario modeling.
Develop a phase-appropriate commercial data and analytics roadmap that supports pre-launch decisions, launch execution and post-launch performance management.
Select, integrate and govern data from market research, claims, specialty pharmacy and distribution, patient services, market access, CRM, finance and other sources to create a reliable commercial source of truth.
Design and implement the commercial technology stack, including CRM, business intelligence and dashboarding, data integration, customer master data, affiliations and account hierarchies.
Establish data governance, quality standards, access controls, privacy and compliance requirements, vendor service levels and documentation in partnership with IT, Legal and Compliance.
Build decision-oriented dashboards and reporting for executive leadership and commercial teams, balancing leading indicators, launch-readiness metrics and business outcomes.
Manage commercial data, analytics and technology partners, ensuring fit-for-purpose solutions, disciplined budgets, strong performance and scalable architecture.
Lead field force sizing, structure, territory design, targeting, customer segmentation, call planning and workload analyses for a focused rare-oncology model.
Build the field operations model, including CRM processes, activity standards, reporting, field communications, operational support and performance-management routines.
Design incentive compensation strategy, measures, governance and administration in partnership with Sales, Human Resources, Finance, Legal and Compliance.
Establish field performance dashboards and analytical approaches that distinguish activity, execution quality, customer response, access progression and business impact.
Establish the commercial operating cadence, planning processes, governance forums, standard work and decision-support tools required for a lean and accountable organization.
Coordinate commercial budget planning and tracking with the Chief Commercial Officer and Finance; provide clear visibility into commitments, forecast changes, investment choices and return expectations.
Partner with Market Access and Finance to incorporate pricing, access, channel, patient services and gross-to-net assumptions into forecasts and performance reporting.
Build and govern the external commercial partner ecosystem, including scopes of work, selection, contracting support, performance metrics, issue resolution and knowledge transfer.
Develop scalable business processes and controls that support commercialization, public-company readiness and compliant operations without creating unnecessary infrastructure.
Build and lead a lean, high-performing Commercial Operations and Business Insights organization, sequencing internal hires and external partners against development and launch milestones.
Serve as Remix's senior internal authority on commercial analytics, operating model, field effectiveness, performance management and launch execution.
Represent Commercial Operations and Business Insights on program teams, launch governance and executive forums; communicate complex analyses and trade-offs with clarity and drive timely decisions.
Maintain effective and compliant working boundaries across Commercial and Medical Affairs while ensuring insights are shared appropriately and enterprise decisions remain coordinated.
Foster a culture of accountability, collaboration, scientific integrity, urgency and patient focus consistent with Remix's values and team behaviors.