Vice President, Head of Biometrics

Climb Bio•Newton, MA

8d•$305,000 - $410,000•Hybrid

About The Position

Climb Bio is a clinical-stage biotechnology company developing therapeutics for patients with immune-mediated diseases. Our product candidates include budoprutug, an anti-CD19 monoclonal antibody that presents us with an exciting opportunity given its broad potential applicability across a number of B-cell mediated diseases, including membranous nephropathy, immune thrombocytopenia, and systemic lupus erythematosus, and CLYM116, an anti-APRIL monoclonal antibody in development for IgA nephropathy. At Climb Bio, our team has a knack for seeing what no one else sees, and a drive to achieve results no one expects. We believe that our combined strength conquers any summit, and our core values – Build Trust, Decide & Commit, Accelerate Impact, and Mark the Moment – guide how we work, collaborate and innovate. They reflect our commitment to patients, each other, and the pursuit of transformative science. We are seeking an experienced and strategic Vice President, Head of Biometrics to lead all biometrics activities across our clinical development programs. This individual will bring deep expertise in biostatistics, a track record of progressing from hands-on statistical leadership into broader biometrics management, and experience operating effectively in a lean biotechnology environment. The VP, Head of Biometrics will provide leadership across Biostatistics, Statistical Programming, and Data Management, overseeing a small team of internal and external resources while serving as the primary biometrics partner to Clinical Development leadership. This role will be highly cross-functional and hands-on, with responsibility for ensuring high-quality data, analyses, and biometrics deliverables that support clinical development and regulatory objectives.

Requirements

MS or PhD in Biostatistics, Statistics, or a related quantitative discipline.
12+ years of experience in the biotechnology or pharmaceutical industry, including substantial experience as a practicing biostatistician.
Demonstrated progression into biometrics leadership with responsibility for biostatistics and broader biometrics functions.
Experience overseeing Statistical Programming and Data Management activities.
Proven success managing outsourced biometrics models and CRO partnerships.
Experience supporting clinical studies through regulatory submissions and health authority interactions.
Strong understanding of clinical trial design, statistical methodologies, CDISC standards, and clinical data workflows.
Ability to operate both strategically and hands-on in a resource-conscious environment.
Excellent communication, collaboration, and leadership skills.

Nice To Haves

Acts as the company's biometrics thought leader and trusted advisor to the CMO.
Delivers high-quality biometrics support across all clinical programs through a combination of internal expertise and external partnerships.
Builds scalable, efficient biometrics capabilities appropriate for a growing biotechnology company.
Ensures data integrity, statistical rigor, and regulatory readiness across the portfolio.

Responsibilities

Lead the biometrics strategy across all clinical development programs.
Serve as the lead statistician and biometrics representative on study teams.
Provide statistical leadership for study design, endpoints, protocol development, sample size determination, and statistical analysis plans.
Oversee all biometrics activities, including biostatistics, statistical programming, and data management.
Manage and mentor a small team of internal and outsourced biometrics professionals.
Provide oversight of CROs and external vendors to ensure high-quality, timely, and cost-effective execution.
Review and interpret clinical data analyses and communicate findings to study teams and executive leadership.
Support regulatory submissions and interactions with health authorities, including preparation and review of biometrics deliverables.
Establish and maintain appropriate biometrics processes, standards, and quality practices.
Partner closely with Clinical Operations, Medical Affairs, Regulatory Affairs, Pharmacovigilance, and external vendors to ensure successful program execution.