Vice President, Clinical Pharmacology & Pharmacometrics

Recursion•New York, NY

9h•$321,800 - $443,080•Remote

About The Position

As Vice President, Clinical Pharmacology & Pharmacometrics, you will set enterprise strategy for clinical pharmacology, pharmacometrics, and model-informed drug development across Recursion’s advancing clinical portfolio. You will translate nonclinical, translational, biomarker, clinical, and quantitative data into development decisions about dose, regimen, population, and study design. You will lead a team spanning Clinical Pharmacology, Pharmacometrics, Translational Modeling, and preclinical PK/PK-PD, working closely with functions including Toxicology, DMPK, Nonclinical Safety, Clinical Biomarkers, Clinical Development, Regulatory, Biostatistics, CMC, Data Science, and Portfolio Strategy. This strategic leadership role spans first-in-human planning through registrational development, regulatory submission, and label strategy. You will build and scale the function, represent Recursion in health authority interactions, and help define clinical pharmacology and pharmacometrics in an AI-native TechBio company. The role is part of Recursion’s Clinical Development organization and reports to the Chief Medical Officer. New York City is the ideal home base, but remote work is considered; remote employees must commit to regular onsite visits for routine work and departmental events. The position is eligible for an annual bonus, equity compensation, and a comprehensive benefits package.

Requirements

Advanced degree in clinical pharmacology, pharmacometrics, pharmaceutical sciences, quantitative pharmacology, biomedical engineering, medicine, pharmacy, or a related field; PhD, PharmD, or MD preferred.
15+ years of biotech or pharmaceutical industry experience, including significant leadership experience in Clinical Pharmacology, Pharmacometrics, Quantitative Pharmacology, or model-informed drug development.
Proven success leading clinical pharmacology strategy across multiple programs, ideally from first-in-human studies through registrational development, submission, and labeling.
Deep expertise in PK, PK/PD, exposure-response, exposure-safety, population PK, PBPK, QSP, dose optimization, dose justification, and model-based clinical trial design.
Experience designing, interpreting, and defending clinical pharmacology studies and analyses in support of global development and regulatory submissions.
Strong understanding of FDA, EMA, MHRA, PMDA, and ICH expectations for clinical pharmacology, pharmacometrics, dose selection, MIDD, and regulatory documentation.
Demonstrated ability to build and lead high-performing teams, influence senior stakeholders, manage external partners, and communicate complex quantitative concepts clearly to executives, program teams, partners, and regulators.

Nice To Haves

Experience in oncology, rare disease, and/or small molecule development.
Experience applying AI, advanced analytics, or automation in clinical pharmacology.

Responsibilities

Set enterprise strategy for Clinical Pharmacology, Pharmacometrics, Translational Modeling, and preclinical-to-clinical quantitative integration across clinical and post-candidate nomination programs.
Own dose strategy from first-in-human planning through registrational development, including dose escalation, dose optimization, exposure-response, safety, efficacy, and label-supporting dose justification.
Lead quantitative development approaches, including population PK, PK/PD, exposure-response, PBPK, QSP, disease progression modeling, and clinical trial simulations.
Design and oversee clinical pharmacology studies, including food effect, DDI, organ impairment, QT/cardiac safety, bioavailability/bioequivalence, mass balance/ADME, and special population studies.
Partner cross-functionally to inform development strategy and decision-making.
Represent Recursion as the clinical pharmacology expert in regulatory interactions and ensure high-quality clinical pharmacology contributions to INDs/CTAs, briefing books, NDAs/BLAs/MAAs, regulatory responses, and labeling.
Represent Clinical Pharmacology and Translational Modeling in program teams, governance forums, regulatory interactions, and alliance settings with external pharma partners.
Build, mentor, and scale a high-performing Clinical Pharmacology and Pharmacometrics function, including internal talent, consultants, CROs, and external modeling partners.
Advance responsible use of AI, automation, and advanced analytics to improve evidence integration, modeling workflows, and clinical development decisions.