Vice President, Clinical Development

Tango Therapeutics•Boston, MA

3h•$332,800 - $499,200•Onsite

About The Position

Tango Therapeutics is seeking a visionary and strategic oncology leader to serve as Vice President, Clinical Development. Reporting directly to the President of Research & Development, this highly visible executive will lead the clinical development strategy from early stage through late stage development. This role offers the opportunity to shape enterprise-wide clinical development strategy, build high-performing development capabilities, and play a pivotal role in advancing transformational therapies for patients with cancer.

Requirements

MD with board certification (or eligibility) in Medical Oncology or a related specialty
14+ years of oncology drug development experience within the biotechnology and/or pharmaceutical industry, spanning early- and late-stage clinical development
Demonstrated success leading clinical development programs, including development of Clinical Development Plans, protocol design, execution of clinical trials, and experience with regulatory interactions and NDA/BLA submission
Expertise designing and executing biomarker-driven oncology clinical trials
Experience leading, mentoring, and developing physicians and/or Clinical Scientists within a matrixed drug development organization
Deep understanding of oncology drug development, ICH-GCP, FDA, and global regulatory requirements
Strong scientific and clinical judgment, with the ability to integrate clinical, safety, pharmacology, biomarker, and competitive data to inform development strategy
Exceptional communication, collaboration, and cross-functional leadership skills, with the ability to influence across diverse scientific and operational teams
Resourceful, adaptable, and execution-oriented, with a passion for advancing innovative therapies for patients with cancer

Responsibilities

Provide strategic and scientific leadership for the clinical development of vopimetostat.
Lead the development and execution of the Clinical Development Plan for the program.
Serve as the clinical development leader on the Global Program Team.
Drive clinical strategy, ensure the successful execution of clinical studies, and integrate emerging clinical, translational, regulatory, and competitive insights to inform key development decisions.
Lead, mentor, and develop a team of Medical Directors and Clinical Scientists.
Represent Tango within the oncology community to advance innovative therapies for patients with cancer.
Lead the clinical development strategy for vopimetostat, including ownership of the Clinical Development Plan and its evolution throughout development.
Serve as the Clinical Development leader and a core member of the Global Program Team, partnering cross-functionally to shape program strategy and deliver development milestones.
Lead the design, execution, analysis, and interpretation of clinical studies, including protocol development, dose optimization, indication expansion, and data-driven decision making.
Lead, mentor, and develop a team of Medical Directors and Clinical Scientists, fostering a culture of scientific excellence, collaboration, accountability, and continuous learning.
Partner with Project Management, Clinical Operations, Regulatory Affairs, Clinical Pharmacology, Biometrics, Translational Medicine, Medical Writing, and Pharmacovigilance to ensure aligned, high-quality program execution.
Lead clinical contributions to regulatory interactions and oversee preparation and review of protocols, Investigator's Brochures, INDs/CTAs, briefing packages, and marketing application components.
Interpret emerging clinical, safety, PK/PD, biomarker, and competitive data to refine development strategy and inform program decisions.
Build and maintain strong relationships with key opinion leaders, investigators, and external collaborators.
Represent Tango at regulatory meetings, scientific congresses, investigator meetings, and advisory boards.
Support scientific communications, including publications, abstracts, and presentations.