Upstream Scientist (Tues-Sat) - Temporary
About The Position
The Upstream Process Development Scientist develops, optimizes, characterizes, and scales upstream bioprocesses supporting production of biologics, vaccines, cell therapies, and other biotechnology products. The role applies expertise in cell culture, fermentation, media development, and bioreactor operations to improve process performance, product quality, and manufacturing efficiency. The scientist works with Process Development, Manufacturing, Analytical Sciences, Quality, and other cross-functional teams to support technology transfer, process validation, and commercial manufacturing. The position also contributes to troubleshooting, continuous improvement, and implementation of bioprocess technologies while maintaining compliance with applicable quality and regulatory standards. This is a temporary position scheduled Tuesday through Saturday, 8 a.m. to 5 p.m.; weekend work might be expected. Candidates living within commuting distance of Malvern, Pennsylvania, are encouraged to apply.
Requirements
- Bachelor's or master's degree in Chemical Engineering, Biochemical Engineering, Biotechnology, Biology, Biochemistry, Microbiology, Pharmaceutical Sciences, or a related scientific discipline.
- Excellent oral and written communication skills.
- Strong computer, scientific, and organizational skills.
- Ability to work independently and as part of a team.
- Self-motivation, adaptability, and a positive attitude.
- Must be authorized to work in the USA indefinitely without restrictions.
Nice To Haves
- Advanced degree in Biotechnology, Biology, Chemistry, Biochemistry, or a related scientific discipline.
- Familiarity with cell passaging, including vial thaw, inoculation, and harvest processes for 5L and 10L bioreactors.
- Certified Biomanufacturing Professional (CBP).
- Lean Six Sigma Green Belt or Black Belt.
- GMP or Bioprocess Manufacturing Training Certification.
- Proficiency recording data via eLN and following SOPs and validation reports.
- Familiarity with GMP and GLP standards.
Responsibilities
- Design, develop, optimize, and scale upstream bioprocesses, including mammalian cell culture and bioreactor operations, for research, clinical, and commercial manufacturing.
- Plan and conduct process development studies to improve cell growth, productivity, product quality, and process robustness.
- Analyze experimental data and identify critical process parameters to support process understanding, scale-up, and technology transfer.
- Collaborate with Manufacturing, Analytical Sciences, Quality, Process Engineering, and other cross-functional teams to advance development programs and support manufacturing operations.
- Author and review study protocols, technical reports, process descriptions, regulatory documentation, and standard operating procedures in compliance with applicable quality standards.
- Troubleshoot process deviations and technical challenges, implement corrective actions, and support continuous improvement to enhance performance and operational efficiency.
- Foster a collaborative, engaged, and team-oriented work environment.
Benefits
- Comprehensive medical coverage
- Dental coverage options
- Vision coverage options
- Life insurance
- Disability insurance
- 401(k) with company match
- Paid vacation
- Paid holidays
