Translational Science Associate Director
About The Position
Are you ready to turn patient biology into decisive clinical strategy for immune-mediated diseases? In this role, you will shape how human insights drive program design, accelerate decision-making, and sharpen product differentiation across cellular, biologic, and small molecule modalities. Your work will directly influence how quickly and confidently we bring transformative therapies to patients. You will lead from the interface of research and development, uniting discovery science, clinical teams, and external partners around clear translational objectives. How would you leverage biomarkers and human evidence to make faster, smarter decisions that change the trajectory of our programs and the lives they aim to improve?
Requirements
- Master’s degree required.
- 5 years of relevant professional experience required, including experience in clinical development or translational science.
- Strong knowledge of the pathogenesis of immune mediated disease and the application of cellular, molecular technologies and models to drive program decisions.
- Prior experience in clinical biomarker strategy development and execution including human target validation, target engagement, and molecular differentiation.
- Significant experience managing CROs for translational studies and biomarkers for clinical trials.
- Detailed understanding of translational and clinical research methodology and biostatistics principles.
- Attention to detail, strive to generate high-quality work, and sense of passion and urgency to achieve team and program goals.
- Demonstrated experience contributing to and leading complex projects.
- Demonstrated track record in delivering results.
- Outstanding verbal and written communication skills.
- Excellent analytical, problem solving and strategic planning skills.
Nice To Haves
- Experience in clinical biomarker development of T-cell therapy and/or other advanced therapeutic modalities in house or with CROs
- Experience in the authoring of relevant sections of regulatory documents.
- Understanding of the full drug development process, with experience across phases of therapeutic development and studies
- Understanding of FDA, EMA, MHRA and ICH GCP guidelines as they pertain to translational strategy.
Responsibilities
- Define and execute integrated translational and biomarker strategies for immune-mediated disease programs, ensuring robust human evidence guides phase progression and differentiation.
- Design and deliver clinical biomarker plans spanning human target validation, target engagement, pharmacodynamic readouts, and molecular differentiation, with clear, pre-specified decision points.
- Build strong target-to-disease hypotheses using human genetics, tissue biology, and mechanistic models; translate insights into program objectives and go/no-go criteria.
- Align discovery and clinical teams to shape protocols, endpoints, sampling strategies, and assay readiness so every patient data point advances mechanistic understanding.
- Lead CROs and collaborators to deliver translational studies to time, quality, and budget; ensure fit-for-purpose assay validation, data standards, and operational excellence.
- Interrogate clinical and translational datasets to refine dose/response, identify responders, and inform next-study design and lifecycle plans; communicate implications clearly to governance bodies.
- Serve as global product team translational lead to enable lifecycle management and new program strategies that build competitive differentiation and patient impact.
- Act as a recognized authority in translational science, solving complex problems with innovative approaches; mentor peers, raise scientific standards, and represent programs externally.
Benefits
- qualified retirement programs
- paid time off (i.e., vacation, holiday, and leaves)
- health, dental, and vision coverage
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What This Job Offers
Job Type
Full-time
Career Level
Senior
