Associate Director, Translational Science
About The Position
Legend Biotech is seeking an Associate Director, Translational Science as part of the Early Drug Development team based in Somerset, NJ. The Associate Director of Translational Science will bridge the gap between early-stage discovery research and clinical development. This role requires a unique blend of deep immunological expertise and advanced computational proficiency. You will be responsible for designing and executing translational strategies, identifying biomarkers, and leveraging large-scale multi-omic datasets to provide actionable insights into mechanism of action (MoA), patient stratification, and drug resistance in both autoimmune and oncology disease area.
Requirements
- PhD or MD/PhD in Immunology, Bioinformatics, Computational Biology, or a related field.
- 5+ years of experience in the biopharmaceutical industry or an equivalent academic leadership role within translational research.
- Extensive knowledge of human auto-immune disease and oncology diseases, specifically in areas such as immuno-oncology, autoimmune diseases, or cell therapy (CAR-T/TCR-T).
- Demonstrated experience with genomic data analysis. Practical and hand on experience data analysis pipeline, ability to guide data integration, knowledge integration from multiple datasets is essential.
- Proven track record in the development, validation, and clinical implementation of complex biomarkers.
- Experience working with relevant disease areas, deep understanding of the biological mechanisms related to diseases(auto-immune, oncology, or/both).
- Strong understanding of regulatory requirements for biomarker-driven clinical trials.
- Excellent project management skills with the ability to lead multiple programs in a fast-paced environment.
- High scientific curiosity, driven, motivated in deep understanding of the biology behind both disease and therapies.
Responsibilities
- Lead the development and execution of program-specific translational plans from lead optimization through Phase II clinical trials.
- Oversee the analysis of high-dimensional datasets (e.g., scRNA-seq, CITE-seq, flow cytometry, and spatial transcriptomics) to identify pharmacodynamic markers and predictive signatures, to interpret and provide insight into the biological mechanisms.
- Partner with Clinical Development and Clinical Operations to implement biomarker assays in clinical protocols and ensure high-quality data collection.
- Manage relationships with Contract Research Organizations (CROs) and academic collaborators for specialized assay development and advanced data processing.
- Represent Translational Science on program teams, providing expert input on disease biology, target engagement, and competitive landscape.
- Author high-quality technical reports, regulatory documents (IND/IB/NDA), and contribute to peer-reviewed publications and conference presentations.
Benefits
- Medical, dental, and vision insurance
- 401(k) retirement plan with a company match that vests fully on day one
- Eight (8) weeks of paid parental leave after just three (3) months of employment
- Paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays
- Flexible spending and health savings accounts
- Life and AD&D insurance
- Short- and long-term disability coverage
- Legal assistance
- Supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
- Voluntary commuter benefits
- Family planning and care resources
- Well-being initiatives
- Peer-to-peer recognition programs
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
