Staff Software Engineer – Data Team #4555

GRAIL•Menlo Park, CA

21h•$169,000 - $224,000•Hybrid

About The Position

GRAIL is seeking a Staff Software Engineer for the Data Team. This team designs, builds, and operates the software systems that manage GRAIL’s end-to-end data lifecycle, from sample ingestion through downstream analysis, while meeting rigorous clinical, regulatory, and privacy standards. Our work directly supports clinical research, operations, and decision-making in the fight against cancer. In this role, you will take technical ownership of systems that produce trusted, analysis-ready datasets for use across GRAIL’s research and clinical programs. This is a software engineering role focused on building complex production-grade systems that work with data in dynamic, regulated environments as opposed to assembling off-the-shelf ETL tools or writing SQL heavy pipelines. This position offers significant autonomy and scope for impact. You’ll collaborate closely with research, clinical lab operations, and scientific teams, and lead efforts to improve how we structure, validate, and deliver critical scientific and clinical data.

Requirements

7+ years of experience building production-grade software systems
Strong software engineering fundamentals, including system design, data modeling, API design, and writing well-tested production code.
Experience building and operating data-intensive software systems, not just declarative pipelines or SQL-only workflows
Proficiency in Go or Python (or similar general-purpose language)
Experience with data modeling, validation, and transforming real-world data into usable formats
BS in Computer Science, Engineering or Bioinformatics, or a related field, or equivalent practical experience

Nice To Haves

2+ years experience working in regulated or clinical data environments (e.g., HIPAA, CLIA, GCP, FDA compliance)
Direct experience working with or supporting scientific teams (e.g., bioinformatics, wet lab, clinical research)
Experience designing systems that manage laboratory or bioinformatics data (e.g., LIMS, sequencing pipelines, assay metadata)
Familiarity with GxP practices and regulatory reporting requirements in clinical studies is a plus
Prior experience working in biotech, diagnostics, or life sciences companies
Experience supporting sample tracking, structured scientific data pipelines, or cross-functional data lifecycle management
Experience designing systems with data sequestration, permissioning, or privacy controls
Experience writing or contributing to software libraries, shared tooling, or reusable components used by other teams
Advanced degree (MS or PhD) in computer science, engineering, bioinformatics or a related discipline

Responsibilities

Design and implement software systems that turn raw clinical, lab, and operational data into reliable, analysis-ready datasets
Partner with scientists, clinicians, lab operations, and data teams to understand data generation, transformation, and usage needs
Develop services, libraries, data models, and workflow components that enforce data integrity, access control, and compliance by design
Navigate complex data requirements such as schema evolution, blinding, consent, and privacy compliance
Collaborate on cross-functional initiatives involving data quality, testing strategy, monitoring, and operational excellence
Lead software engineering efforts for long-lived systems that must evolve alongside active clinical and research programs
Mentor engineers and collaborate with scientists to ensure software decisions support both technical and scientific outcomes
Contribute to documentation, onboarding materials, and processes that support cross-functional adoption and data literacy across teams
Participate in incident response or investigation processes related to data quality or availability issues in production systems