Staff Software Engineer, Variant Classification
About The Position
Labcorp is seeking a Staff Software Engineer to join its Labcorp Genetics Variant Classification team. The team builds and maintains tools that define, store, and provide detailed variant-, sample-, and test-level information for accurate variant interpretation and report generation. Its services support genetic variant interpretation reporting and assay development across platforms including SDS, VDB, Argus, iVEP, Evidence Service, MoonPy, Cerebro, Universal Transcript Archive, SeqRepo, and Assay CMS. The role designs, builds, and maintains systems that transform raw bioinformatic data into useful variant and sample information, while scaling storage and supplying annotations needed for interpretation. It also automates evidence placement and classification and supports test-content and assay-development initiatives. The engineer works with data scientists, variant scientists, and software developers, and provides technical leadership across teams by setting direction, addressing ambiguous problems, and aligning partner-team roadmaps with broader business goals. This is a full-time, exempt salaried position on a first-shift schedule, normally Monday through Friday, 8:00 a.m. to 5:00 p.m. local time. Business needs may occasionally require flexibility, including earlier, later, or additional hours, with reasonable notice when possible. Applicants living within 35 miles of Burlington or Durham, North Carolina, follow a hybrid schedule requiring at least three in-office days per week at an assigned location.
Requirements
- Bachelor's degree.
- At least 10 years of recent professional software development experience.
- At least 10 years of Python experience at intermediate level or higher.
- At least 10 years of experience with relational databases and web development frameworks.
- At least 10 years of experience with front-end technologies such as React, Angular, Vue.js, JavaScript/TypeScript, and HTML/CSS.
- At least 10 years of experience with RESTful APIs and microservices architecture.
- At least 10 years of experience with CI/CD pipelines and DevOps practices.
- At least 10 years of experience with a cloud platform such as AWS, Azure, or GCP.
- Ability to communicate effectively in writing and verbally with scientific and non-scientific audiences.
- Effectiveness using GitHub Copilot, Claude Code, or similar LLM tools for coding, testing, and documentation.
Nice To Haves
- Master's degree or Ph.D. in Bioinformatics, Computational Biology, or life sciences.
- At least 8 years of experience mentoring and developing senior and junior engineers across multiple teams.
- At least 8 years of experience defining technical vision and driving multi-year roadmaps.
- At least 3 years of experience with bioinformatic tools and annotation.
- At least 3 years of experience with variant databases and genomic data resources such as ClinVar, gnomAD, or HGMD.
- At least 3 years of experience in Spark, text mining, natural language processing, semantic enrichment, ontologies, data mining, or machine learning/AI.
- At least 3 years of experience with public-domain biomedical terminologies such as MeSH, NCIt, or HGNC.
- At least 3 years of experience translating complex scientific questions into information solutions.
- Current or prior Labcorp experience.
Responsibilities
- Design and build tools that define, store, and provide meaningful variant-, sample-, and test-level information for variant interpretation and report generation.
- Develop and maintain systems that translate raw bioinformatic data into variant- and sample-level information, including registration, normalization, observation groups, and quality metrics.
- Scale and optimize storage of sample-level information to support growing data needs.
- Source, maintain, and provide variant-level annotations needed for accurate variant interpretation.
- Automate evidence placement and classification for variant interpretation.
- Support test-content and assay-development initiatives.
- Collaborate with data scientists, variant scientists, and software developers to design and implement solutions that meet stakeholder requirements.
- Own and deliver product or platform goals across multiple years and teams.
- Define the vision, scope, and technical approach for large projects with organization-wide implications.
- Identify, prioritize, and drive solutions to ambiguous, open-ended problems across multiple teams.
- Influence partner-team roadmaps to align with broader business goals.
- Serve as a role model and technical authority for engineers across multiple teams.
- Communicate effectively with scientific and non-scientific audiences.
- Use GitHub Copilot, Claude Code, or similar LLM tools to accelerate coding, testing, and documentation.
Benefits
- Medical insurance
- Dental insurance
- Vision insurance
- Life insurance
- Short-term and long-term disability coverage
- 401(k)
- Paid Time Off (PTO) or Flexible Time Off (FTO)
- Tuition reimbursement
- Employee Stock Purchase Plan
- Annual bonus eligibility under the Labcorp Bonus Plan, subject to plan terms and performance
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What This Job Offers
Job Type
Full-time
Career Level
Senior
