Staff Scientist

University of Chicago • Hyde Park, IL

2d • Onsite

About The Position

The principal contribution of a Staff Scientist is leading translational research projects under the mentorship of Dr. Chuan He in the Department of Chemistry. The He Lab seeks a highly experienced scientist with expertise in drug discovery, chemical biology, epitranscriptomics, and next-generation sequencing technologies. The candidate will lead research projects involving RNA modifications, gene regulation, and the discovery and application of small-molecule chemical probes and therapeutic agents to investigate biological mechanisms and disease processes. The candidate must hold a Ph.D. degree in molecular biology, chemistry, biochemistry, or a related field and have over 4 years of postdoctoral research experience.

Requirements

• PhD degree in molecular biology, chemistry, biochemistry, or a related field
• Over 4 years of postdoctoral research experience
• Knowledge of basic computer proficiency including computer programs and standard laboratory equipment.
• Knowledge of relevant scientific fields.
• Knowledge of regulatory policies and procedures.
• Demonstrated problem-solving, organization, analytical, and coordination skills including attention to detail.
• Demonstrated excellent oral and written communication skills.
• Demonstrated ability to read and comprehend scientific and technical literature, and methods to stay abreast of developments in the field.
• Ability to work independently and as a part of a team and interact with a diverse workforce.
• Ability to think creatively.
• Demonstrated ability to articulate their scientific discoveries both in written publications and in talks.

Nice To Haves

• Previous Postdoctoral experience in the field.

Responsibilities

• Perform routine and advanced molecular biology experiments, including nucleic acid extraction, purification, quantification, PCR/RT-PCR, and gel-based analysis.
• Prepare and process RNA and DNA samples for next-generation sequencing (NGS) workflows, including library preparation and QC steps.
• Design, evaluate, and apply small-molecule chemical probes and therapeutic agents to investigate the functions of DNA/RNA modification pathways and their potential as therapeutic targets.
• Support large-scale research projects aimed at studying biological mechanisms and disease processes using chemical biology and molecular biology approaches.
• Operates in a highly collaborative mode with all members of the group and with others in the Institute and with off-campus collaborators.
• Under general supervision of principal investigator, supervise and/or assist with the complex technical duties in a laboratory doing non-clinical research.
• Compile documents and assists with interpreting presentations or reports stemming from scientific contributions in the laboratory.
• Gives frequent internal and occasional external talks and tutorials on the thinking and work progress.
• Leads the contributions to scientific writing and publications, including protocols and grants.
• Mentor and supervise lab technician and undergraduate students within the group.
• Performs experiments and collects and analyzes data.
• Participates in the promotion of a research project.
• May present work at scientific meetings.
• Performs other related work as needed.

Benefits

• health
• retirement
• paid time off

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree