Staff Scientist - Biochemistry

Washington University in St. Louis • Baltimore, MD

2d • Onsite

About The Position

Center for Drug Discovery is seeking a highly motivated researcher to join our multidisciplinary drug discovery team. This role offers a unique opportunity to bridge the gap between academic innovation and "real-world" therapeutic development. The successful candidate will be responsible for lead optimization of novel protein aggregate degraders, utilizing both proteasome- and autophagosome-targeting modalities. The candidate will receive hands-on training focusing on the enhancement of potency and optimization of drug-like properties (stability, permeability, PK/PD model, etc.). Additionally, the researcher will develop innovative chemical tools and probes to interrogate fundamental biologic processes and mechanism of action. Designs research protocols. Assists in developing and conducting research projects, including experiment design, data analysis and documentation of experiment results.

Requirements

• Master’s degree or combination of education and/or experience may substitute for minimum education.
• Laboratory Operations (3 Years)
• Analytical Problem Solving
• Communication
• Computer Literacy
• Data Analysis
• Data Interpretations

Nice To Haves

• Ph.D. - Doctor of Philosophy - Organic Chemistry

Responsibilities

• Following instructions and discussions with the principal investigator, designs research protocols, including developing procedures for the collection, verification and management of data.
• Synthesizes heterocyclic binders and degraders.
• Troubleshoots multi-step heterocyclic synthesis independently.
• Assists with grant preparation and reporting.
• Performs complex statistical analysis of data collected and writes interpretative reports.
• Verifies the correctness of the data submitted and makes recommendations based on these analyses.
• Documents research topics and prepares and submits papers based on research work to publications and committees for publication or presentation to peers.
• Solves practical problems relating to difficulties with equipment or test subjects.
• Suggests technical or procedural improvements in testing methods.
• Conducts literature searches related to research project.
• Performs other duties as assigned.

Benefits

• Up to 22 days of vacation, 10 recognized holidays, and sick time.
• Competitive health insurance packages with priority appointments and lower copays/coinsurance.
• Free Metro transit U-Pass for eligible employees.
• Defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%.
• Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more!
• 4 weeks of caregiver leave to bond with your new child.
• Family care resources are also available for your continued childcare needs.
• Adult care resources.
• Covers the cost of tuition for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years with us.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior