Staff Business Analyst

Guardant Health • Palo Alto, CA

1d • Hybrid

About The Position

We are seeking a highly motivated Staff Business Analyst with a strong background in genomics and oncology to join our team. You will be embedded at the front of product development for Guardant Health's clinical and genomic data applications. You bring years of direct experience in molecular diagnostics or clinical oncology, and you use that depth daily to shape what gets built, how clinical data is modeled, and what it means for every downstream consumer.

Requirements

• 7+ years as a Business Analyst or equivalent, with the majority spent in genomics, molecular diagnostics, oncology, clinical data systems, or precision medicine. Deep domain experience is required
• Bachelor's or advanced degree in Life Sciences, Bioinformatics, Genomics, Health Informatics, or a related scientific discipline.
• Expert-level written and verbal communication, documenting data specifications, and stakeholder communications that are clear, precise, and actionable without further interpretation. You are equally effective in a room of clinicians, a product review, or an engineering planning session.
• Hands-on experience building or supporting clinical or genomic data applications. Querying data, running data analysis on analytics databases.
• Deep working knowledge of genomic data: variants, biomarkers, assay panels, clinical annotations, and how these translate into structured data within production systems.
• Experience in HIPAA-compliant healthcare environments. Familiarity with clinical data governance and data quality standards.

Responsibilities

• Collaborate with domain owners and business leaders in Real-World Evidence, Medical Affairs, Biopharma, Product management, and Data Engineering to gather and document business requirements. Ensure clarity of needs and objectives specific to genomic data analytics and real-world clinical outcomes.
• Operate as part of the product and engineering team, owning the problem space from early discovery through production release. Shape what gets built by driving clarity on requirements, domain and business context.
• Own requirements end-to-end for clinical and genomic data products. Drive conversations with domain authority, challenge assumptions, identify gaps, and resolve ambiguity independently.
• Assess the full downstream impact when a new assay, product, biomarker, or data source is introduced including changes to how clinical concepts are represented across the platform, data model and business logic updates, and implications for downstream consumers.
• Maintain authoritative documentation of clinical data models, business rules, data mappings, and lineage. Serve as the source of truth for how clinical and genomic concepts are represented and consumed across the platform.
• Serve as a subject matter expert in oncology and genomic data workflows, providing guidance to users and stakeholders. Facilitate user training and support the adoption of new product features.

Benefits

• Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time.
• The annualized base salary ranges for the primary location and any additional locations are listed below. This range does not include benefits or, if applicable, bonus, commission, or equity.
• Each candidate’s compensation offer will be based on multiple factors including, but not limited to, geography, experience, education, job-related skills, job duties, and business need.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior