Staff Business Analyst

Guardant Health•Palo Alto, CA

3d•$120,955 - $195,700•Hybrid

About The Position

Guardant Health is seeking a highly motivated Staff Business Analyst with a strong background in genomics and oncology to join their team. This role will be embedded at the front of product development for Guardant Health's clinical and genomic data applications. The ideal candidate will bring years of direct experience in molecular diagnostics or clinical oncology to shape product development, clinical data modeling, and downstream data consumption.

Requirements

7+ years as a Business Analyst or equivalent, with the majority spent in genomics, molecular diagnostics, oncology, clinical data systems, or precision medicine. Deep domain experience is required.
Bachelor's or advanced degree in Life Sciences, Bioinformatics, Genomics, Health Informatics, or a related scientific discipline.
Expert-level written and verbal communication, documenting data specifications, and stakeholder communications that are clear, precise, and actionable without further interpretation.
Hands-on experience building or supporting clinical or genomic data applications.
Querying data, running data analysis on analytics databases.
Deep working knowledge of genomic data: variants, biomarkers, assay panels, clinical annotations, and how these translate into structured data within production systems.
Experience in HIPAA-compliant healthcare environments.
Familiarity with clinical data governance and data quality standards.

Responsibilities

Collaborate with domain owners and business leaders in Real-World Evidence, Medical Affairs, Biopharma, Product management, and Data Engineering to gather and document business requirements, ensuring clarity of needs and objectives specific to genomic data analytics and real-world clinical outcomes.
Operate as part of the product and engineering team, owning the problem space from early discovery through production release and shaping product development by driving clarity on requirements, domain, and business context.
Own requirements end-to-end for clinical and genomic data products, driving conversations with domain authorities, challenging assumptions, identifying gaps, and resolving ambiguity independently.
Assess the full downstream impact when a new assay, product, biomarker, or data source is introduced, including changes to how clinical concepts are represented across the platform, data model and business logic updates, and implications for downstream consumers.
Maintain authoritative documentation of clinical data models, business rules, data mappings, and lineage, serving as the source of truth for how clinical and genomic concepts are represented and consumed across the platform.
Serve as a subject matter expert in oncology and genomic data workflows, providing guidance to users and stakeholders, facilitating user training, and supporting the adoption of new product features.