Sr. Scientist

Legend Biotech US•Philadelphia, PA

6d•Onsite

About The Position

Legend Biotech is seeking an initiative-taking and creative scientist to grow our pipeline efforts. The candidate will be part of Legend Biotech, a leading cell therapy company with a commercial CAR drug product CARVYKTI and an attractive pipeline portfolio. The candidate will be an integral part of our Philadelphia R&D team, whose aim is to research, develop and advance the next generation of cell therapies using innovative in vivo delivery technologies and create novel CAR therapy to treat a wide range of cancer and autoimmune disease indications. This position will focus on in-vivo CAR. The position requires enthusiasm, passion, outstanding skills in the art, diligence, and a desire to create new medicines for patients. Expertise in immunology and/or oncology is required. The ideal candidate will be a highly motivated individual who enjoys fast paced biotech environment. You thrive in a collaborative work environment and are skilled at advancing multiple projects concurrently. Knowledge of state-of-art immunotherapy and its applications.

Requirements

PhD in Immunology or related discipline.
4 years of experience in the field of cell and gene therapy, in vivo CAR-T experience preferred.
Extensive experience in immune cell-based analytics and assay development including but not limited to advanced multi-parameter flow-cytometry, immunogenicity assay such as cytotoxicity assay, cytokine release ELISA/MSD multiplex assays.
Experience with lentivirus particle characterization and quantification using molecular (VCN) and flow-based assays.
Experience with solid tumor models and in vivo cell-specific gene delivery is a plus.
Track record of productivity is evidenced by publications or patents.
Be able to work independently to plan and timely execute research projects
Deep knowledge of immunology and immunotherapy; a deep understanding of solid tumor models is preferred
Proficient in advanced gene delivery methods using LVV, VLP or LNP technologies
Strong experience with lentivirus production, tittering and transduction.
Working molecular biology and cellular biology knowledge in design and evaluation of modified viral vectors
Strong multitasking, problem-solving and collaborative skills
Excellent verbal and written communication skills

Responsibilities

Lead, design and optimize research with aims of exploring next generation cell therapies using in-vivo CAR-T.
Contribute to project creation and formation through dissection of published literature to find novel solutions to in-vivo cell therapy problems.
Isolate immune cells from leukopak or blood of healthy donors or patients and execute the evaluation of in-vivo CAR virus using a battery of in-vitro assays and in-vivo mice models.
Perform treatment of solid tumor research requiring cell biology techniques including cell culture, transfection, FACS, and cell-based functional assays.
Package and titer engineered viruses to infect immune cells in vitro and in vivo; Characterize virus particles with protein and PCR based assays; Measure transduction rate using flow and VCN analysis.
Generate, manage, evaluate, and maintain critical data in a highly organized manner, including the use of ELN.
Deliver result to meet timeline with accountability through presentation to a wide range of audiences of internal group meetings and other forums.
Maintain compliance with GLP and EHS protocols.