Sr. Scientist

Inotiv•Saint Louis, MO

7d•Onsite

About The Position

The Senior Method Development Scientist will perform method development utilizing contemporary mass spectrometry techniques (LC-MS/MS & HRMS) for large and small molecules (proteins, antibodies, ADCs oligonucleotides, etc.). The senior method development scientist will be a member of the DMPK team and will serve as a subject matter expert for new proposals, evaluating feasibility of LC-MS/MS method development, and troubleshooting challenging methods across a wide variety of species and matrices. Join us in embracing research and science to impact the health and well-being of people all over the world.

Requirements

Experience, skills, and abilities must include knowledge of contemporary bioanalytical techniques, including wet chemistry separations, liquid chromatography, and mass spectrometric analysis (LC-MS/MS, HRMS), instrument operation, maintenance, and data processing.
Proven track record of method development for large and small molecules
Ability to incorporate software in the maintenance of databases to collate and catalog records and inventory.
Working knowledge of laboratory software, system software, and Microsoft applications
Independence in the laboratory and data work-up phases of research.
A working knowledge and awareness of general laboratory procedures.
Good written and oral communication skills.
Ability to adhere to all safety regulations and procedures.
PhD in Organic Chemistry, Biochemistry, Analytical Chemistry or related discipline with 2+ years of industrial bioanalytical experience following Post Doctoral training
M.Sc. in a discipline previously described with 5+ years direct industrial bioanalytical experience

Nice To Haves

Candidates possessing working knowledge of in vitro metabolism/biotransformation, Pharmacokinetic modeling, analysis, interpretation and simulation desirable

Responsibilities

Develop highly sensitive LC-MS/MS and HRMS methods for large (oligonucleotides, proteins, antibodies, ADCs, biomarkers, etc) and small molecules in biological matrices.
Utilize and interpret scientific theories, concepts, techniques in bioanalytical and mass spectrometry studies and accepts leadership role in developing novel scientific approaches
Coordinate, facilitate, and implement intercompany method transfers and implementation of incoming transfers from clients.
Communicate project timelines, status, and data to Principal Investigators, Project Management, and clients effectively addressing any issues that may arise.
Ability to coordinate and execute on multiple projects simultaneously and responsive to unscheduled deadlines and client needs.
Demonstrate an understanding of Best Practices, SOPs and Good Laboratory Practice Regulations (21 CFR, Part 58) as these relate to study-specific services provided, this job description, and general facility operations.
Training and mentoring junior scientists within and across departments
Collaborate with leadership on long-range planning and strategy for departmental growth
Performs other duties as assigned.