Sr Scientist, Genomic Sciences and Target Discovery

Alkermes•Waltham, MA

1d•$151,000 - $170,000•Onsite

About The Position

We are seeking an enthusiastic and highly motivated Senior Scientist to join the Genomic Sciences and Target Discovery team within Alkermes R&D, focusing on the application of genome-editing technologies to validate therapeutic hypotheses in vitro and in vivo for central nervous system (CNS) disorders.

Requirements

Ph.D. in Neuroscience, Molecular Biology, Genomics, or a related field with a minimum of 3 years of relevant experience in functional genomics, preferably within industry-based CNS drug discovery and development.
Proficiency in human (Mendelian/population genetics) and model organism genetics
Expertise in CRISPR-based gene editing techniques, including CRISPR/Cas9, CRISPRa, and CRISPRi.
Experience with in vivo CRISPR delivery methods such as AAV, lipid nanoparticles, or electroporation for targeting CNS circuits.
Strong background in neuroanatomy and neurocircuitry, with experience in functional validation of gene edits in preclinical models.
Proficiency in standard molecular biology and tissue culture techniques, including developing and maintaining CRISPR-edited cell lines.
Familiarity with in vivo rodent models, behavioral assays, and CNS-relevant phenotypic assessments.
Strong data analysis and interpretation skills, with experience using bioinformatics tools for genomic analysis.
Excellent communication and collaboration skills in a cross-disciplinary research environment.

Nice To Haves

Experience with single-cell RNA sequencing, spatial transcriptomics, or electrophysiological techniques to assess gene function in CNS models.
Proficiency with computational tools (Python, R, or Unix CLI) for analyzing CRISPR screening data.

Responsibilities

Design, develop, and execute CRISPR-based functional genomics strategies to validate therapeutic hypotheses in vitro and in preclinical models of CNS diseases.
Utilize CRISPR/Cas9, CRISPRa, and CRISPRi approaches to modulate gene expression and investigate target biology in the context of neuroanatomy and neurocircuitry.
Develop and optimize CRISPR delivery methodologies, including viral and non-viral delivery systems, for precise gene editing in the CNS.
Establish and validate CRISPR-edited rodent models using molecular, cellular, and behavioral readouts to assess target engagement and functional outcomes.
Collaborate cross-functionally with neuroscience, pharmacology, and translational teams to integrate functional genomics insights into drug discovery programs.
Perform molecular and cellular assays, including PCR, NGS, immunohistochemistry, and single-cell sequencing, to confirm CRISPR-mediated gene modifications.
Maintain detailed records of experimental design, execution, and data interpretation in accordance with corporate documentation standards.
Keep abreast of emerging CRISPR technologies and functional genomics advancements to drive innovation within the team.
Effectively communicate findings and recommendations to internal and external stakeholders.