Sr. Scientist – Gene Delivery

AstraZeneca • Waltham, MA

9d • Onsite

About The Position

We are seeking an innovative Senior Scientist to join the Cellular Resilience team and contribute to groundbreaking early-discovery research at the intersection of gene delivery and cell therapy. The successful candidate will leverage their expertise in gene delivery, vector design, and/or cellular engineering to develop the next generation of cellular therapies.

Requirements

• PhD with 0-5 years of post-graduate experience in a relevant field, including but not limited to bioengineering, chemical engineering, biomedical engineering, molecular biology, synthetic biology, biochemistry, and immunology.
• Demonstrated ability to advance their field through high-impact scientific publications and/or patents.
• Ability to independently conceive, design, execute, and draw conclusions for projects with minimal guidance.
• Proactive, highly self-motivated, and able to thrive in a workplace where goals may shift.

Nice To Haves

• Experience in state-of-the-art gene delivery modalities, including but not limited to VLPs, LNPs, exosomes, AAV, lentivirus, and electroporation.
• Experience in protein engineering, with an emphasis on designing protein/DNA constructs and integrating constructs into appropriate vectors.

Responsibilities

• Vector design and production: Conceive, perform in silico design of, and experimentally produce genetic vectors.
• Cell engineering: Engineer cell lines and primary cells using viral and non-viral techniques.
• Assay development: Develop in vitro cellular assays with an emphasis on high-throughput readouts such as multicolores flow cytometry and imaging.
• Data analysis and communication: Analyze and interpret complex experimental data and present findings to internal and external stakeholders.
• Cross-functional collaboration: Collaborate with cross-functional teams to advance research projects from concept through preclinical development.

Benefits

• Competitive remuneration and benefits apply
• Competitive Total Reward program including a market driven base salary, bonus and long-term incentive.
• Generous paid time off program
• Comprehensive benefits package
• Eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles
• Qualified retirement programs
• Paid time off (i.e., vacation, holiday, and leaves)
• Health, dental, and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree