Sr Scientist -- Biologics Engineering, Protein Therapeutics

Gilead Sciences•Foster City, CA

2d•$169,320 - $219,120•Onsite

About The Position

The Protein Therapeutics Department at Gilead Sciences is seeking a highly motivated Senior Scientist to join our Biologic Engineering team at our Foster City, CA site. Protein Therapeutics is responsible for the discovery and advancement of innovative large-molecule therapeutics, including complex multi-specific next-generation biologics. This role will focus on the engineering of bispecific and multispecific antibody formats and structure-guided protein design, integrating both experimental and computational approaches. Candidates with demonstrated accomplishment and experience in engineering broadly neutralizing therapeutic proteins to HIV-1, hepatitis, and respiratory virus will be prioritized. The successful candidate will contribute to discovery-stage programs and help advance differentiated biologics toward clinical development across Virology, Oncology, and Inflammation therapeutic areas. This role will sit on-site in Foster City, CA.

Requirements

Bachelor's Degree and Eight Years’ Experience OR Masters' Degree and Six Years’ Experience OR Ph.D.
Strong communication skills and ability to work effectively in a fast-paced, collaborative environment.

Nice To Haves

Ph.D. in Protein Engineering, Structural Biology, Biochemistry, Immunology, or a related discipline with postdoctoral experience and 3+ years of relevant experience
Strong background in antibody engineering, with demonstrated experience in bispecific and/or multi-specific formats to develop broadly neutralizing anti-HIV-1 antibodies.
Experience in antiviral or infectious disease antibody discovery, including but not limited to work on broadly neutralizing antibodies or viral targets.
Familiarity with AI/ML applications in protein engineering, including sequence-to-structure modeling or generative design approaches.
Hands-on experience with molecular biology techniques, protein purification and characterization methods, including biophysical and biochemical assays.
Demonstrated ability to contribute to scientific innovation, reflected through publications, patents, or advancement of drug candidates.
Demonstrated a strong track record of independent critical thinking and scientific achievement in research, exemplified by publications in highly regarded journals, conference presentations, or generation of intellectual property.

Responsibilities

Drive the design, engineering, and optimization of bispecific and multi-specific antibodies, including format innovation and evaluation of novel architectures to enable differentiated therapeutic mechanisms.
Apply structure-guided protein engineering approaches to design and optimize antiviral antibodies, including improving potency, breadth, stability, and developability.
Contribute to antibody discovery efforts targeting viral pathogens, including identification, screening, and characterization of candidate molecules.
Integrate AI/ML-driven protein engineering tools (e.g., protein language models, structure prediction, and in silico design) to accelerate biologics discovery and optimization workflows.
Design and execute experiments involving molecular biology, cloning, protein expression, purification, and biochemical/biophysical characterization of therapeutic candidates.
Work collaboratively within a multidisciplinary environment including protein engineering, structural biology, virology, and computational sciences to advance programs.
Provide scientific insights and experimental data to support candidate selection, lead optimization, and program strategy.
Contribute to scientific publications, patent filings, and internal/external presentations.