Sr Research Scientist - Metabolomics
About The Position
The UMass Chan Metabolomics Core Facility is seeking an enthusiastic and motivated individual to support metabolism-based research projects across a variety of experimental models using high-resolution, accurate-mass liquid-chromatography mass spectrometry. Under the direction of the Core Director, the Sr Research Scientist provides operational support to the metabolomics and lipidomics platform by conducting bench-level experiments. The role collaborates with researchers to develop and apply LC/MS-based metabolomics and lipidomics approaches, prioritizes and organizes workflows, and works independently and as part of a team to ensure high-quality data acquisition in a state-of-the-art laboratory.
Requirements
- Ph.D. in analytical chemistry, (bio)chemistry, or a related field.
- At least 7 years of research experience, including a minimum of 3 years of experience in metabolomics and/or lipidomics, or at least 1 year of postdoctoral research experience.
- Familiarity with high-resolution mass spectrometers, such as Orbitraps.
- Experience with liquid chromatography, including standard analytical flow.
- Willingness to work in a collaborative environment and strong customer-service acumen.
- Recent bench work experience.
- Ability to prepare research reports.
- Good verbal and written communication skills.
- Demonstrated ability to understand scientific, experimental, and/or research theory.
Nice To Haves
- Experience with lipidomics in addition to metabolomics.
- Experience with gas chromatography, NMR, or other methods of analyzing metabolism.
- Understanding of the use of stable isotopes in tracing experiments.
- Broad knowledge of open-source, high-resolution, accurate-mass data analysis software.
- Experience in advanced data processing and analysis, such as using Matlab, R, or Python.
- Familiarity with statistical methods used in larger cohort studies.
- Willingness to explore and adopt AI into the metabolomics workflow.
Responsibilities
- Serve as project lead on multiple projects with different collaborators.
- Assist with weekly cleaning and calibration of LCMS instrumentation and data quality checks.
- Prepare samples for metabolomics and lipidomics experiments.
- Optimize extraction protocols.
- Assist researchers with metabolite extractions.
- Perform LC/MS/MS experiments for targeted and untargeted metabolomics and lipidomics.
- Perform data analysis using software such as TraceFinder, Compound Discoverer, and LipidSearch.
- Consult with researchers on experimental design and data interpretation.
- Produce reports and share them with collaborators.
- Participate in grant writing and manuscript preparation.
- Present data at group meetings and may attend scientific conferences.
- Operate, maintain, and troubleshoot a variety of mass spectrometers.
- Develop new metabolomics and lipidomics methods and workflows when needed.
- Assist with general laboratory tasks as needed.
- Maintain detailed records and adhere to SOPs.
- Supervise and train new laboratory personnel and junior laboratory members.
- Serve as EHS contact and monitor and enforce laboratory safety standards.
- Perform other duties as assigned.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
