Sr Research Associate, Biology

Gilead Sciences•Foster City, CA

2d•$94,945 - $122,870

About The Position

Protein Therapeutics in Gilead Research has an exciting opportunity for a Senior Research Associate to join the Protein Sciences team. The successful candidate will be a highly motivated scientist with hands-on knowledge in recombinant antibody purification, bioconjugation and protein analytics. The candidate will demonstrate the ability to produce and interpret experimental data with scientific rigor and independence. With guidance from the manager, the individual will work effectively with cross-functional project teams to generate and validate therapeutic proteins and tool molecules, including monoclonal and bispecific antibodies, immunocytokines, ADCs and other complex biologics. The ideal candidate is hard-working, team-oriented, professional, diligent, and motivated to expand his/her technical and scientific skills.

Requirements

Bachelor's Degree and 2 Years’ Experience OR Masters' Degree
BS in Biology, Biochemistry, Chemistry or related field with at least 2+ years of relevant experience (3+ years preferred) or MS with above listed characteristics and techniques for the position
Strong work ethic and detailed record-keeping are required
Ability to multi-task and work in a fast-paced team environment

Nice To Haves

At least 2 years of direct experience in purifying and characterizing a variety of recombinant proteins, particularly monoclonal antibodies and complex biologics (e.g., bi/multi-specific antibodies)
Hands-on experience in purification techniques including affinity, ion exchange, size exclusion, hydrophobic interaction chromatography using AKTA Avant/Pure
Proficiency with various analytical protein characterization techniques such as SEC-HPLC or UHPLC, SDS-PAGE or CE-SDS, Endosafe
Proficiency with performing and analyzing data for ADC QC assays
Familiarity with bioconjugation methods
Ability to perform method development and write protocols
Familiarity with other protein characterization technologies (DLS, SEC-MALS, LC/MS, IEX/HIC-HPLC)
Operating experience with various automation instruments e.g., autosamplers, automated liquid handling systems
Training and experience in automation system programing or scripting

Responsibilities

Perform protein purification and characterization for quality and document work in electronic lab notebook and various informatics systems to support the preclinical development of biopharmaceutical programs across multiple therapeutic areas.
Prepare technical reports, summaries, and check in protein samples into the sample bank.
Use good oral and written communication skills to relay scientific data and update collaborators of purification status and challenges.
Actively participate in group meetings, present results, interpret data, draw conclusions and propose next steps for the presented work.
Maintain awareness of cutting-edge technical developments and scientific knowledge and apply these where possible to improve work quality and efficiency.