Sr. Manager, Bioinformatics

Roche•San Diego, CA

6d•$170,500 - $316,600•Hybrid

About The Position

Roche is seeking a visionary and deeply technical leader to champion the customer-facing bioinformatics and software strategy for their revolutionary Axelios sequencing platform. As they launch XOOS, an ecosystem of bioinformatics tools, this role will bridge the gap between new customers and internal development teams. The position involves leading a team of bioinformatics scientists and software engineers to create bespoke solutions, resolve technical roadblocks, and engage in collaborative research with early adopters. The Axelios platform operates on a different paradigm than traditional Sequencing-by-Synthesis (SBS), requiring the role to educate the market, ensure seamless migration to their tools, and translate customer feedback into actionable development pipelines.

Requirements

Ph.D. in Bioinformatics, Computational Biology, Computer Science, or a related quantitative field with 4+ years of industry experience; OR a Master’s degree in Bioinformatics, Computational Biology, Computer Science, or a related quantitative field with 6+ years of industry experience.
8+ years of progressive experience in next-generation sequencing (NGS) bioinformatics, with a demonstrated track record of leadership in an industry setting.
Significant level of expertise and comprehensive knowledge of the NGS landscape, clinical genomics space, and secondary/tertiary data analysis pipelines.
Demonstrated leadership experience.
High level of proficiency with cloud architectures (AWS, Azure, or GCP), modern software development practices, pipeline frameworks (e.g., Nextflow, Snakemake), and scripting languages (Python, R).
Demonstrated experience in product commercialization, go-to-market execution, or technical customer enablement (similar to scaling platforms like DRAGEN).

Nice To Haves

Demonstrated experience working with non-SBS technologies (e.g., long-read sequencing or alternative modalities).
Exceptional communication, presentation, and relationship-building skills.
Demonstrated ability to navigate complex, sensitive technical discussions with world-class clinical and scientific executives.
Ability to navigate the complexities of a global organization, adapt to changing business needs and work collaboratively within a diverse and inclusive environment.
Excellent organizational skills, including the ability to efficiently evaluate, prioritize and handle multiple changing projects and priorities; ability to complete work in a timely, accurate and thorough manner.

Responsibilities

Serve as the primary executive-level technical contact for new customers, driving deep adoption of the XOOS bioinformatics ecosystem across major clinical and research applications.
Build, inspire, and manage a high-performing team of customer-facing bioinformatics scientists and solutions architects.
Lead the creation of customized workflows, data analysis pipelines, and software integrations to solve unique customer pain points and accelerate Axelios platform adoption.
Partner with strategic early-adopter customers on collaborative research projects, co-authoring whitepapers, and demonstrating the unique capabilities of Axelios non-SBS data.
Act as a critical strategic partner to internal Bioinformatics and Software R&D teams, synthesizing market requirements, feature requests, and technical friction points into the product roadmap.
Collaborate with Sales and Product Management to support high-value customer engagements, technical evaluations, and complex contract closures.