Sr. Director of Sponsor Operations

Crio Inc.

3d•$160,000 - $185,000•Remote

About The Position

The Senior Director of Sponsor Operations is responsible for building, scaling, and leading CRIO’s enterprise sponsor business, including Central eSource programs across global pharmaceutical and CRO organizations. This role owns the end to end sponsor lifecycle from initial engagement through multi study execution and long term expansion. The Head of Sponsor Operations ensures consistent, high quality delivery across all enterprise sponsor programs while establishing scalable operational frameworks that enable CRIO to grow its sponsor footprint effectively. A critical component of this role is ownership of clinical data strategy and execution across sponsor programs, including data standards, integration alignment, data quality, and regulatory compliance. This individual ensures that CRIO’s eSource data is structured, mapped, validated, and delivered in a way that meets sponsor expectations and industry requirements. Operating at the intersection of sponsor strategy, clinical operations, and technical data delivery, this role partners closely with Product, Engineering, and Customer Experience to align enterprise sponsor needs with CRIO’s platform capabilities and long term roadmap.

Requirements

10+ years of experience in clinical research technology, data management, sponsor operations, or clinical trial systems
5-7+ years of operational team and/or personnel management
Strong background in clinical data management, including: CDISC standards (CDASH, USDM, SDTM, etc.), Data mapping and transformation, Data validation and quality processes
Proven experience managing enterprise sponsor or CRO relationships across multiple studies or programs
Deep understanding of clinical trial workflows, site operations, and regulatory requirements
Experience working with eSource, EDC, CTMS, or related clinical platforms
Demonstrated ability to lead complex, data intensive, cross functional programs
Exceptional communication and executive presence

Nice To Haves

Exposure with Central eSource concept models or similar sponsor site integrated workflows
Familiarity with HL7 FHIR, API based integrations, or structured data exchange models
Experience overseeing data migration or large scale data transformation initiatives
Background in CRO, sponsor organization, or clinical technology vendor environment
Prior experience scaling teams in a high growth environment

Responsibilities

Own the operational strategy for all enterprise sponsor programs including Lilly, ICON, Moderna, and future enterprise accounts
Partner with Sales and Executive Leadership to support enterprise deal strategy, solution design, and expansion planning
Define scalable Central eSource operating models across sponsor organizations
Identify opportunities to expand sponsor adoption across additional studies, geographies, and use cases
Own delivery across all active and planned studies within enterprise sponsor portfolios
Ensure consistency in execution, timelines, and quality across all sponsor engagements
Establish standardized workflows, templates, and delivery frameworks across sponsors
Drive visibility through executive level reporting on portfolio health, risks, and performance
Establish governance models for enterprise sponsor accounts including regular executive reviews and QBR structures
Serve as senior leadership point of contact for sponsor organizations
Lead high level sponsor discussions related to scope, timelines, data expectations, and escalations
Own the clinical data framework for all sponsor programs, ensuring alignment with industry standards and sponsor expectations
Oversee CDASH mapping, data structuring, and standardization across all studies
Ensure consistency and quality of data capture, validation, and downstream usability
Define and enforce data governance practices across sponsor portfolios
Oversee the alignment of eSource data with EDC systems, ensuring accurate, complete, and compliant data transfer
Ensure integration outputs meet sponsor requirements for data quality, structure, and format
Establish processes for - Data review and validation, Query management alignment with sponsor workflows, XML and structured data output review
Oversee enterprise Central eSource design frameworks, ensuring alignment with sponsor protocols, regulatory requirements, and site workflows
Define data capture logic, workflow structures, and role based access models across studies
Drive standardization across study configuration, amendment processes, and UAT strategies
Establish repeatable deployment models that balance flexibility with scalability
Identify and champion opportunities to embed AI-driven automation across sponsor workflows, including Central eSource design configuration, data validation, query management, and amendment processing
Partner with Product and Engineering to define enterprise requirements for AI-assisted capabilities, such as intelligent data capture, protocol deviation detection, and EDC integration quality checks
Stay ahead of emerging AI applications in clinical data and eSource, translating sponsor needs and operational patterns into actionable input for CRIO's AI product roadmap
Partner with Product and Engineering to define and prioritize enterprise integration requirements across EDC, CTMS, eRegulatory, and external systems
Ensure data integrity and consistency across all integration points
Serve as executive escalation point for complex technical, data, and integration challenges
Lead coordination across Sponsor Operations, Central eSource design, Data Migration, Product, Engineering, and Customer Experience teams
Ensure alignment between sponsor requirements and internal delivery capabilities
Identify and resolve systemic gaps across workflows, data handling, and handoffs
Partner with Product Leadership to influence roadmap priorities based on enterprise data and integration needs
Drive accountability across all functions involved in sponsor delivery