Sr. Director - Macrocycle Chemistry

Eli Lilly and Company • Us, IN

1d • Onsite

About The Position

Eli Lilly and Company is seeking an experienced and innovative senior research scientist with strong background in synthetic macrocycles to join Early Molecule Design (EMD) within Lilly Small Molecule Discovery (LSMD) at Indianapolis, Indiana. This individual will drive hit-finding and hit-to-lead chemistry for Lilly’s synthetic macrocycle platform, applying deep expertise in macrocycle design and ADME/DMPK to advance orally bioavailable synthetic macrocycles against challenging targets across Cardiometabolic & Renal (CMR), Immunology, Neuroscience, and Oncology. The Early Molecule Discovery team's mission is to identify Hits and deliver optimized Leads that advance into strong drug candidates and, ultimately, breakthrough medicines. We are searching for scientific experts recognized for excellence in Hit identification, Lead discovery, and medicinal chemistry to drive the advancement of our portfolio. The EMD team operates as an integrated, multi-site organization spanning Indianapolis, San Diego, Louisville (CO), and Alcobendas (Spain). This role offers exposure to a broad and innovative portfolio with meaningful opportunities to shape program strategy, influence molecule quality, and collaborate across a world-class cross-functional organization.

Requirements

• Ph.D. in Medicinal Chemistry, Organic Chemistry, Peptide chemistry, Chemical Biology, or a related field
• Minimum of 8 years of relevant industry experience in drug discovery

Nice To Haves

• Demonstrated hands-on experience in macrocycle hit-finding and the design and synthesis of macrocyclic peptides or macrocyclic small molecules
• Strong foundation in ADME/DMPK principles and their application to drug design, including oral bioavailability, metabolic stability, and PK/PD relationships
• Track record of productive multi-disciplinary collaboration in a pharmaceutical or biotechnology research environment
• Experience across multiple therapeutic areas or modalities, including both macrocyclic peptides and macrocyclic small molecules
• Experience with challenging or undrugged targets requiring non-traditional modality approaches
• Understanding of clinical translation considerations, including candidate nomination criteria and IND-enabling studies
• Strong scientific publication or patent record
• Excellent written and oral communication skills; ability to present complex scientific data clearly to diverse audiences

Responsibilities

• Serve as a recognized subject matter expert in macrocyclic small molecules and/or macrocyclic peptides.
• Drive hit-finding strategy and deliver high-quality, chemically tractable macrocycle hits against novel and challenging targets.
• Design and synthesize macrocyclic small molecules and macrocyclic peptides enabling hit-to-lead progression across multiple therapeutic areas.
• Apply structure-activity relationship (SAR) knowledge to drive iterative DMTA cycles, balancing potency, selectivity, and drug-like properties
• Collaborate closely with Biology, DMPK, Computational Chemistry, and other cross-functional partners to develop and execute efficient molecule design strategies
• Leverage ADME/DMPK principles to optimize oral bioavailability, metabolic stability, permeability, and pharmacokinetic profiles of synthetic macrocycles
• Contribute to program strategy discussions, including target product profile (TPP) development and go/no-go decision frameworks
• Effectively communicate scientific findings to internal stakeholders at all levels, including program teams, portfolio boards, and leadership
• Maintain thorough and timely documentation in electronic laboratory notebooks (ELN) in accordance with IP and regulatory requirements
• Mentor junior scientists and contribute to a collaborative, scientifically rigorous team culture

Benefits

• competitive compensation and benefits package
• company bonus
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree