Sr. Director, Clinical Pharmacology

CytomX Therapeutics, Inc.•South San Francisco, CA

8d•$302,000•Hybrid

About The Position

Sr. Director, Clinical Pharmacology Headquarters Location: South San Francisco, CA, Company relocating to Emeryville, CA Fall of 2026 Candidate Location: Hybrid Travel Required: 5-10% Reports To: Vice President, Clinical Pharmacology Department: Clinical Pharmacology Position Type: Full-time About CytomX Therapeutics: CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel PROBODY® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX’s robust and differentiated pipeline comprises therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), T-cell engagers, and immune modulators such as cytokines. CytomX’s clinical-stage pipeline includes CX-2051 and CX-801. Learn more at www.cytomX.com. Who You Are and What You’ll Do: The Senior Director of Clinical Pharmacology will provide program-level leadership for clinical pharmacology across key programs within CytomX’s portfolio of Probody® therapeutics. Reporting to the VP, Clinical Pharmacology, this role will focus on execution and delivery of clinical pharmacology strategies, integrating PK/PD, biomarker, and clinical data to support dose selection, indication expansion, and regulatory interaction including BLA readiness. This individual will play a highly hands-on role in advancing programs from Phase 1 through late-stage development, ensuring high-quality analyses and regulatory deliverables to support successful submissions. Job Responsibilities: Program-Level Leadership & Execution • Lead clinical pharmacology activities for assigned programs, from Phase 1 through late-stage development • Execute and deliver PK/PD, exposure-response, and data integration strategies to support dose selection and regimen optimization • Translate clinical pharmacology insights into clear, actionable recommendations for program teams • Partner with the VP to align program strategies with overall functional direction Regulatory Execution & BLA Readiness • Lead preparation of clinical pharmacology deliverables for Regulatory submissions, including exposure–response analyses, dose justification, and summaries • Support regulatory interactions by preparing materials and addressing health authority questions • Ensure all outputs are high quality, compliant, and submission-ready Study Support & Data Interpretation • Provide clinical pharmacology input into study design across Phase 1–3 trials • Support indication expansion cohorts and combination strategies through data-driven insights • Ensure timely and accurate delivery of clinical pharmacology analyses Cross-functional Collaboration • Work closely with Clinical Development, Regulatory Affairs, Biometrics, and Translational Sciences • Contribute to integrated development plans and support decision-making • Communicate complex data clearly to cross-functional teams Vendor & Operational Management • Manage external CROs and vendors supporting PK/PD and modeling activities • Ensure delivery of analyses aligned with timelines and quality expectations • Maintain strong oversight of outsourced work Minimum Qualifications: • BS (≥20 years), MS (≥17 years), PharmD/PhD (≥ 15 years) in clinical pharmacology or related function in industry • Experience in oncology or biologics • Experience supporting late-stage development and registrational programs • Strong experience in PK/PD, exposure-response, and clinical data interpretation • Experience supporting dose justification and regulatory deliverables • Strong ability to lead program-level execution in a matrixed environment • Proven track record of delivering high-quality regulatory outputs • Effective communicator with cross-functional teams • Experience working in biotech or fast-paced environments Preferred Qualifications: • Familiarity with biologics and/or oncology How You Will Work: • Demonstrates collaboration and teamwork. Works well with others and understands that collaboration leads to better results. • Possesses strong communication skills. Communicates clearly, concisely, and professionally. Listens actively to build understanding. • Exhibits strong interpersonal skills and self-awareness. Builds and cultivates strong and enduring relationships with others. Acts with humility and understands own strengths and weaknesses. • Shows continuous improvement and a commitment to self-management and development. Operates with a continuous improvement mindset and continuously seeks to expand own knowledge and capabilities. • Demonstrates a patient focus. Puts the patient first in actions and decisions taken. • Contributes to strategy and innovation. Contributes to or leads elevating and actionable strategies. Ideates and creates unique opportunities to advance the organization. • Demonstrates leadership and a commitment to organizational values. Takes ownership and has a strong sense of personal accountability. Consistently achieves or exceeds goals and expectations. Puts significant emphasis on living / upholding company values. • Demonstrates ability and commitment to building effective teams. Attracts, develops, and retains diverse top talent. Aligns, mobilizes, and engages others to achieve and sustain peak performance. • Has a track record of driving vision and purpose in teams. Compensation, Benefits, and So Much More • The target salary for this role based on the primary location for this position in California is $302,000 per year. Actual offer amounts are determined by factors such as experience, qualifications, geographic location, and other job-related factors permitted by law. • A great environment where we work collaboratively, leverage each other’s strengths, and work toward a shared vision with our common goals of doing the best thing for patients. • A robust and enduring approach to your development and career growth fueled by a strong learning curriculum and career guidance that helps you understand how you can grow your career at CytomX. • A robust and highly competitive total rewards program that helps you achieve your compensation goals while supporting a great work / life balance. Conditions of Employment • Background investigations are required for all positions at CytomX, consistent with applicable law. CytomX’s Commitment to Diversity, Equity, Inclusion, and Belonging (DEIB) CytomX believes that DEIB helps drive our success, and we encourage candidates from all identities, backgrounds, and abilities to apply. We are an equal opportunity employer committed to building an inclusive, innovative work environment with employees who reflect our values and ultimately, serve our patients. Therefore, in all aspects of the employment process, we provide employment opportunities to all qualified applicants without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity or expression, pregnancy, medical condition related to pregnancy, creed, ancestry, national origin, marital status, genetic information, or military status, or any other protected status in accordance with applicable law. Further, we are committed to the full inclusion of all qualified individuals. As part of this commitment, we (and the agencies we work with) will assist individuals who have a disability with any reasonable accommodation requests related to employment, including completing the application process, interviewing, completing any pre-employment testing, participating in the employee selection process, and/or to perform essential job functions where the requested accommodation does not impose an undue hardship. If you have a disability and require reasonable accommodation, or need other assistance in applying for or interviewing for this position, please direct your inquiries to Human Resources, at [email protected] Notice to Recruiters/Staffing Agencies Recruiters and staffing agencies should not contact CytomX Therapeutics through this page. We require that all Recruitment Vendors (e.g., search firms, recruitment agencies and staffing companies) have a fully executed, formal written agreement on file with CytomX prior to submitting candidates. Any resumes submitted through the website or directly by Recruitment Vendors will be considered unsolicited. Unsolicited vendor submissions do not constitute any actual or implied contract with CytomX, and CytomX will not be responsible for any purported fees. For more information, please contact our HR team at [email protected] Please review our Applicant Personal Information Processing Notice to understand what types of personal information we collect from job applicants and why we process such information.

Requirements

BS (≥20 years), MS (≥17 years), PharmD/PhD (≥ 15 years) in clinical pharmacology or related function in industry
Experience in oncology or biologics
Experience supporting late-stage development and registrational programs
Strong experience in PK/PD, exposure-response, and clinical data interpretation
Experience supporting dose justification and regulatory deliverables
Strong ability to lead program-level execution in a matrixed environment
Proven track record of delivering high-quality regulatory outputs
Effective communicator with cross-functional teams
Experience working in biotech or fast-paced environments

Nice To Haves

Familiarity with biologics and/or oncology

Responsibilities

Lead clinical pharmacology activities for assigned programs, from Phase 1 through late-stage development
Execute and deliver PK/PD, exposure-response, and data integration strategies to support dose selection and regimen optimization
Translate clinical pharmacology insights into clear, actionable recommendations for program teams
Partner with the VP to align program strategies with overall functional direction
Lead preparation of clinical pharmacology deliverables for Regulatory submissions, including exposure–response analyses, dose justification, and summaries
Support regulatory interactions by preparing materials and addressing health authority questions
Ensure all outputs are high quality, compliant, and submission-ready
Provide clinical pharmacology input into study design across Phase 1–3 trials
Support indication expansion cohorts and combination strategies through data-driven insights
Ensure timely and accurate delivery of clinical pharmacology analyses
Work closely with Clinical Development, Regulatory Affairs, Biometrics, and Translational Sciences
Contribute to integrated development plans and support decision-making
Communicate complex data clearly to cross-functional teams
Manage external CROs and vendors supporting PK/PD and modeling activities
Ensure delivery of analyses aligned with timelines and quality expectations
Maintain strong oversight of outsourced work

Benefits

A great environment where we work collaboratively, leverage each other’s strengths, and work toward a shared vision with our common goals of doing the best thing for patients.
A robust and enduring approach to your development and career growth fueled by a strong learning curriculum and career guidance that helps you understand how you can grow your career at CytomX.
A robust and highly competitive total rewards program that helps you achieve your compensation goals while supporting a great work / life balance.

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